Double Positive Celldoi:10.1007/978-1-4020-6754-9_4835It expresses both CD4 and CD8 proteins but may die within the thymus. T cell, lymphocytesSpringer Netherlands
Thymocytes displaying self-reactive T cell receptors usually undergo negative selection in the thymus. Here we demonstrate that agonist peptides can promote positive selection of immature double-positive thymocytes into distinct lineages, varying with the agonist concentration and the animal's age. Microar...
The molecular markers CD4 and CD8—defining helper T cells and killer T cells, respectively—were once considered mutually exclusive. But "double positive" CD4+-CD8+ T cells have lately been discovered in people in various states of health. In a May study published in theJournal of Experimental...
Even though the expression of CD4 and CD8 on thymocytesis considered mutually exclusive, CD4+ CD8+ double-positive T cells (DP) represent a small subset of T lymphocytes that have been described in the peripheral blood of normal individuals, as well as in some pathological conditions. In partic...
The cells were briefly centrifuged at 100×g for 1 min to avoid the formation of a tight cell pellet and resuspended in 200 μL of 1× perm/wash buffer. After staining with 488-labeled phalloidin for 20 min at room temperature, the cells were centrifuged at 100×g for 1 min ...
et al. Inhibition of autophagy in EBV-positive Burkitt’s lymphoma cells enhances EBV lytic genes expression and replication. Cell Death Dis. 6, e1876 (2015). Article PubMed PubMed Central CAS Google Scholar Liu, B. et al. Hepatitis B virus X protein inhibits autophagic degradation by ...
BLNK ## PC_ 3 ## Positive: HLA-DQA1, CD79A, CD79B, HLA-DQB1, HLA-DPB1, CD74, HLA-DPA1, MS4A1, HLA-DRB1, HLA-DRB5 ## HLA-DRA, HLA-DQA2, TCL1A, LINC00926, HLA-DMB, HLA-DMA, HVCN1, FCRLA, IRF8, BLNK ## Negative: PPBP, PF4, SDPR, SPARC, GNG11, NRGN, GP9, RGS...
(Prof Ju Chen BS, Prof Y Lin BS); Ivonescimab versus pembrolizumab for PD-L1-positive non-small cell lung cancer (HARMONi-2): a randomised, double-blind, phase 3 study in ChinaAnwen Xiong*, Lei Wang*, Jianhua Chen*, Lin Wu*, Baogang Liu, Jun Yao, Hua Zhong, Jie Li, Ying Cheng...
This effect was associated with the abrogation of transient accumulation of leukemia cells in S and G2/M cell cycle phases after drug treatment. In conclusion, ATR - Chk1 axis was strongly activated in BCR/ABL-positive cells and contributed to the resistance to DNA cross-linking agents causing...
samples were quantified using the 525/30 nm channel. Single color (pool of the transfected samples for each group) and no color (untransfected cells) control cell populations were used to set up gating. Single color (GFP positive cells for knock-in) had higher intensity than the un...