网络释义 1. 双阳性细胞 ...gative cells),随后发CD4+CD8+双阳性细胞(double positive cells),并受一以严格的选择。 zhidao.baidu.com|基于25个网页
The frequency of CD4CD8double-positive (DP) T cells is highly associated with a variety of diseases. Recently, we used high-throughput single-cell RNA sequencing to show that circulating DP T cells in cynomolgus monkeys comprise nine heterogeneous populations. To better understand the characteristics...
Self-reactivity in thymic double-positive cells commits cells to a CD8αα lineage with characteristics of innate immune cells. Nat Immunol 5, 597–605 (2004). https://doi.org/10.1038/ni1070 Download citation Received09 December 2003 Accepted15 March 2004 Published09 May 2004 Issue Date01 June...
The molecular markers CD4 and CD8—defining helper T cells and killer T cells, respectively—were once considered mutually exclusive. But "double positive" CD4+-CD8+ T cells have lately been discovered in people in various states of health. In a May study published in theJournal of Experimental...
Even though the expression of CD4 and CD8 on thymocytesis considered mutually exclusive, CD4+ CD8+ double-positive T cells (DP) represent a small subset of T lymphocytes that have been described in the peripheral blood of normal individuals, as well as in some pathological conditions. In partic...
Mushroom acidic glycosphingolipid induction of cytokine secretion from murine T cells and proliferation of NK1.1 {alpha}/{beta} TCR-double positive cells i... Mushroom acidic glycosphingolipid induction of cytokine secretion from murine T cells and proliferation of NK1.1 a/b TCR-double positive...
However, despite the positive effects of ferroptosis on tumor therapy, it is often difficult and risky to apply in practice. Research has shown that ferroptosis can not only be used as a cancer treatment, but also damage normal cells and cause other diseases. How to accurately target cancer ...
T cells generated from thymopoiesis are essential for the immune system, and recent single-cell studies have contributed to our understanding of the development of thymocytes at the genetic and epigenetic levels. However, the development of double-positive (DP) T cells, which comprise the majority...
articles nkt cells derive from double-positive thymocytes that are positively selected by cd1d L Gapin,JL Matsuda,CD Surh,... 被引量: 0发表: 0年 Genetic Evidence Supporting Selection of the Vα14i NKT Cell Lineage from Double-Positive Thymocyte Precursors By using genetic analyses, we show...
Natural Treg cells constitute an independent thymus-derived T-cell lineage whose developmental program in humans is still ill-defined. Here, we provide evidence of a Treg-cell differentiation pathway at the double positive (DP) stage, prior to commitment to the CD4+ or CD8+ lineage, in ...