The frequency of CD4CD8double-positive (DP) T cells is highly associated with a variety of diseases. Recently, we used high-throughput single-cell RNA sequencing to show that circulating DP T cells in cynomolgus monkeys comprise nine heterogeneous populations. To better understand the characteristics...
Even though the expression of CD4 and CD8 on thymocytesis considered mutually exclusive, CD4+ CD8+ double-positive T cells (DP) represent a small subset of T lymphocytes that have been described in the peripheral blood of normal individuals, as well as in some pathological conditions. In partic...
The molecular markers CD4 and CD8—defining helper T cells and killer T cells, respectively—were once considered mutually exclusive. But "double positive" CD4+-CD8+ T cells have lately been discovered in people in various states of health. In a May study published in theJournal of Experimental...
et al. A unique DNA methylation signature defines a population of IFN-gamma/IL-4 double-positive T cells during helminth infection. Eur J Immunol 44, 1835-1841 (2014).Deaton AM, Cook PC, De Sousa D, Phythian-Adams AT, Bird A, MacDonald AS. A unique DNA methylation signature defines a...
网络释义 1. 双阳性细胞 ...gative cells),随后发CD4+CD8+双阳性细胞(double positive cells),并受一以严格的选择。 zhidao.baidu.com|基于25个网页
In this study, we used an in-depth comparative transriptomic analysis of intra-melanoma DP T cells and CD4 and CD8 single positive (SP) T cells, to better comprehend the origin of this DP phenotype, and define the transcriptomic signature of activated DP T cells. We observed that intra-...
Objective To investigate the relationship between levels of Tc1/Tc2 ,CD 4/CD 25 double positive T cells and SLE Methods The cytokine profile were determined by intracellular staining with tri color fluroscence. Results The results showed that 3 of CD 8 positive T cell samples from the patients...
Thymocytes displaying self-reactive T cell receptors usually undergo negative selection in the thymus. Here we demonstrate that agonist peptides can promote positive selection of immature double-positive thymocytes into distinct lineages, varying with th
articles nkt cells derive from double-positive thymocytes that are positively selected by cd1d L Gapin,JL Matsuda,CD Surh,... 被引量: 0发表: 0年 Genetic Evidence Supporting Selection of the Vα14i NKT Cell Lineage from Double-Positive Thymocyte Precursors By using genetic analyses, we show...
T cells generated from thymopoiesis are essential for the immune system, and recent single-cell studies have contributed to our understanding of the development of thymocytes at the genetic and epigenetic levels. However, the development of double-positive (DP) T cells, which comprise the majority...