In general, transcription factors have two distinct functional activities. A DNA binding activity referred to as its ability to bind the specific DNA sequence present in the regulatory element of genes is responsible for directing TFs to the vicinity of the promoter. A transactivating potential is ...
Eukaryotic transcription factors recognize specific DNA sequence motifs, but are also endowed with generic, non-specific DNA-binding activity. How these bi... P Pellanda,M Dalsass,M Filipuzzi,... - 《Embo Journal》 被引量: 0发表: 2021年 Kappa B-specific DNA binding proteins: Role in the ...
Regulation of gene expression by DNA binding Py-Im polyamides: Targeting transcription factor-DNA interfaces Many human diseases are caused by dysregulated gene expression. The oversupply or overactivity of one or more transcription factors may be required for the... DervanPB - 《International Chemica...
NLysine Acetylation of a Bacterial Transcription Factor Inhibits Its DNA-Binding Activity S Thao,CSJ Chen,H Zhu,... 被引量: 0发表: 2010年 Regulation of p53 activity through lysine methylation p53 is a tumour suppressor that regulates the cellular response to genotoxic stresses. p53 is a short...
DNA-binding activity of a maize heat shock transcription factor (HSF) was induced by heat shock of a whole cell extract at 44掳C. Addition of the calcium i... Bing,Li,Hong-Tao,... - 《Plant & Cell Physiology》 被引量: 181发表: 2004年 Regulation of p53 by metal ions and by antiox...
Interactions between Hairy/Enhancer of Split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptiona... In the developing pancreas, the onset of exocrine differentiation is driven by the activity of the PTF1 (pancreas transcription factor 1) tr...
In striking contrast, the second activity exhibits high affinity for the ends of double-stranded DNA in a sequence-unspecific manner and is attributable to the heterodimeric Ku autoantigen. Notably, transcription of Ku is induced during mid-late G0/G1with kinetics similar to the TR gene. Ku is...
In contrast to the lower Mr factor, the activity of the 130,000 Mr factor did not appear to be general in that it increased the DNA binding of truncated androgen receptors that had been over-expressed in yeast but had no effect on the binding of either full-length androgen receptors or ...
We have examined the activity of the Xenopus heat-shock transcription factor (HSF) in extracts from stressed and unstressed embryos at various stages of development using DNA mobility shift analysis. A specific interaction between HSF and a synthetic oligonucleotide corresponding to the proximal heat-sh...
transcription factor is a fusion protein of the prokaryotic Tet repressor, TetR, conferring DNA-binding capacity that is abrogated upon binding by tetracycline (Tet-Off), with the acidic transactivation domain of the herpes simplex virus-encoded transcription factor VP16 driving transgene expression25....