In general, transcription factors have two distinct functional activities. A DNA binding activity referred to as its ability to bind the specific DNA sequence present in the regulatory element of genes is responsible for directing TFs to the vicinity of the promoter. A transactivating potential is ...
Integrated requirement of non-specific and sequence-specific DNA binding in Myc-driven transcription Eukaryotic transcription factors recognize specific DNA sequence motifs, but are also endowed with generic, non-specific DNA-binding activity. How these bi... P Pellanda,M Dalsass,M Filipuzzi,... -...
Expression and DNA binding activity of the tomato transcription factor RIN (ripening inhibitor). Zhu HL,Zhu BZ,Li YC,Shao Y,Wang XG,Xie YH,Chen AJ,Luo JJ,Jia XY,Luo YB. Bioscience Biotechnology and Biochemistry . 2008Hong-Liang Zhu,Ben-Zhong Zhu,Ying-Cong Li,etc.Expression and DNA ...
Regulation of gene expression by DNA binding Py-Im polyamides: Targeting transcription factor-DNA interfaces Many human diseases are caused by dysregulated gene expression. The oversupply or overactivity of one or more transcription factors may be required for the... DervanPB - 《International Chemica...
3. Wasmuth, E.V., Hoover, E.A., Antar, A., Klinge, S., Chen, Y., and Sawyers, C.L. (2020). Modulation of androgen receptor DNA binding activity through direct interaction with the ETS transcription factor ...
000 cells. KAS-seq enables definition of a group of enhancers that are single-stranded and enrich unique sequence motifs. These enhancers are associated with specific transcription-factor binding and exhibit more enhancer–promoter interactions than typical enhancers do. Under conditions that inhibit ...
We have examined the activity of the Xenopus heat-shock transcription factor (HSF) in extracts from stressed and unstressed embryos at various stages of development using DNA mobility shift analysis. A specific interaction between HSF and a synthetic oligonucleotide corresponding to the proximal heat-sh...
DNA-binding activity of a maize heat shock transcription factor (HSF) was induced by heat shock of a whole cell extract at 44掳C. Addition of the calcium i... Bing,Li,Hong-Tao,... - 《Plant & Cell Physiology》 被引量: 181发表: 2004年 Regulation of p53 by metal ions and by antiox...
DBD, DNA-binding domain; HMG, high mobility group; IHF, integration host factor; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; OCT-1, octamer binding transcription factor 1; TBP, TATA-box binding protein; TFIIIA, transcription factor IIIA. The HMG proteins are a di...
NtcB box. The sequential binding of NtcA and NtcB induces looping back of promoter DNA towards RNAP, enabling the assembly of a fully activated TAC bound with two activators. Together with biochemical assays, we propose a ‘DNA looping’ mechanism of cooperative transcription activation in ...