The RIPE3b1 DNA binding factor plays a critical role in pancreatic islet β cell-specific and glucose-regulated transcription of the insulin gene. Recently it was shown that RIPE3b1 binding activity in β cell nuclear extracts is reduced by treatment with either calf intestinal alkaline phosphatase...
本期小编分享的这篇微生物活性的表征对于理解微生物群落的基本生物学是必不可少的,因为微生物组的功能是由其生物化学活性(“活的”)的群落成员定义的题为 RNA-based ampli con sequen cingis ineffe ctivein measu ring meta bolic activity inenv iron mental micro bial commu nities(基于RNA的扩增子测序在...
Acetylation regulates transcription factor activity at multiple levels. CREB-binding protein (CBP) possesses an intrinsic acetyltransferase activity capable of acetylating nucleosomal histones as well as several nonhistone prot... E Soutoglou,N Katrakili,I Talianidis - 《Molecular Cell》 被引量: 763...
aSirt1 deacetylase activity has also been implicated in the repair of DNA damage, through its ability to deacetylate the tumor suppressor p53 [26,52], a sequence-specific transcription factor that regulates processes such as the cell cycle, cell death, and DNA repair, in response to a variety...
DNA sequence analysis revealed a binding motif for octamer-binding transcription factor 1 (OCT-1) in the deleted fragment. Mutation of this OCT-1 binding motif resulted in a similar effect as the deletion experiment, i.e. it increased the basal promoter activity and abolished the response to ...
that the DNA binding activity of the Runt domain can be sensitively controlled by a reduction/oxidization (redox) mechanism and that the β subunit acts to stabilize the activated state of the Runt domain, apart from and in addition to its known effect to increase the DNA binding affinity....
The other promoter fragments had promoter activity similar to or lower than the full-length promoter, showing that these regions contain transcription factor binding sites mediating negative regulation. The ZBED6 gene is located in the first intron of zinc finger CCCH type containing 11A (ZC3H11A)...
DNA sequence analysis revealed a binding motif for octamer-binding transcription factor 1 (OCT-1) in the deleted fragment. Mutation of this OCT-1 binding motif resulted in a similar effect as the deletion experiment, i.e. it increased the basal promoter activity and abolished the response to ...
Article: The DNA-dependent ATPase activity associated with the class Ii basic transcription factor BTF2/TFIIH
PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage Abstract Protein kinase B (PKB/Akt) is ubiquitously expressed in cells. Phosphorylation of its multiple targets in response to various stimuli, including growth factors or cytokines,...