在人类细胞中, 这两种乙酰化过程分别由CBP(CREB-binding protein)/P300和MOF(male absent on the first)负责, 这两种乙酰化标记都对DDR的正确响应十分关键[110]. 而去乙酰化酶HDAC1(histone deacetylase 1)或HDAC2的缺陷会造成H3K56和H4K16的持续乙酰化, 抑制cNHEJ修复途径. 这暗示进行cNHEJ修复时可能需要相对...
的为富含AT的区域的区域 说明:说明:AT富含区在转录的终止和起始中均起重要的作用富含区在转录的终止和起始中均起重要的作用 nRho factor has an ATP-dependent RNA-DNA helicase activity nStill have a hairpin but no poly(U) stretch nIn both cases, the signal to terminate transcription is present in ...
As DNA polymerases generally recognize recessed 3′ termini for binding and activity without preferred sequence context, the role of sequence preferences for DNA polymerases is unclear, and preferred binding is, perhaps, unexpected. However, the examples noted above indicate that these enzymes do, in...
In both cases, we find UNG2 activity and protein to be completely dispensable for virus replication. Moreover, we find that virion-associated UNG2 does not affect the loss of infectivity caused by Apobec3G. CAS-2 JCR-Q1 SCIE 134 被引用 · 0 笔记 引用 dUTPase-minus caprine arthritis-...
32、含量的减少U串的缩短或缺失(5)DNA上与U串对应的为富含AT的区域说明:AT富含区在转录的终止和起始中均起重要的作用,(二)Rhodependent,RhofactorhasanATP-dependentRNA-DNAhelicaseactivityStillhaveahairpinbutnopoly(U)stretchInbothcases,thesignaltoterminatetranscriptionispresentinthenewlytranscribedRNA,notintheDNA...