Allostery is a pervasive principle to regulate protein function. Growing evidence suggests that also DNA is capable of transmitting allosteric signals. Yet, whether and how DNA-mediated allostery plays a regulatory role in gene expression remained unclea
to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity...
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The amino acid chain of MYC protein consists of 88 residues, ten of which are known DNA-binding sites indicating that their distances to DNA are less than 3.5 Å. Applying RF classifier, which takes a majority vote among the random tree classifiers, with our first feature (f𝕁𝕊𝔻f...
It seems counterintuitive that a primer-dependent DNA polymerase (PDDP) would bind significantly more tightly to one sequence than another. Unlike structure (i.e., the presence or absence of a 3′-recessed termini) and composition (RNA or DNA), there is no clear role for sequence specificity...
“This is the complete package, from assembly to analysis.” Marjorie Beggs, Arkana Laboratories Workflows to support your research We offer a wide variety of workflows for comprehensive sequence analysis; assembly and analysis of NGS, long-read, and transcriptomics data; and protein sequence analysis...
DNA methylation is a crucial epigenetic mark for activity-dependent gene expression in neurons. Very little is known about how synaptic signals impact promoter methylation in neuronal nuclei. In this study we show that protein levels of the principal de
and also just .txt) into an image. A unique visualisation of DNA / RNA residing in text files, AminoSee is a way to render arbitrarily large files - due to support for streamed processing - into a static size PNG image. Special thanks and shot-outs to David Hilbert who invented it in...
3. Probe molecule (Modified DNA aptamer technology) We focused on the use of aptamers to develop a probe molecule system because aptamers are a nucleic acid having a material- recognition function similar to that of antibodies. Ribonucleic acid (RNA) aptamer technology was established by research ...
The interactions of metal cations with nucleic acid have been used in the design of DNA-based nanosensors [12]. It was reported that Cu2+was mainly attached to the phosphate group of nucleic acids and also can bind to the basic groups of nucleic acid [13]. Cu2+mainly binds to the N7...