Sequencing of nucleic acids with nanopores has emerged as a powerful tool offering rapid readout, high accuracy, low cost and portability. This label-free method for sequencing at the single-molecule level is an achievement on its own. However, nanopores also show promise for the technologically ...
The conventional and next-generation techniques have tremendously progressed and created wealthy opportunities in different research areas, especially in metagenomic approaches, as sequencing play a significant role in its analysis. Therefore, this chapter intends to provide information about past applied and...
This report reviews the main sequencing technologies and explains why genetic variation is important in clinical testing. It then discusses some of the significant research initiatives that impact sequencing applications. Of particular interest is a discussion of population-scale sequencing projects throughou...
(Figure 2). DNA may also be sequenced for epigenetic studies—e.g., methylation analysis (also known asbisulfite sequencing or Bis-Seq) and DNA–protein interaction sequencing (commonly known as ChIP-Seq), which are not covered...
Because a comprehensive review is impractical, we provide vignettes that illustrate how high-throughput DNA sequencing is impacting hematology. These highlight applications of these approaches for disease diagnosis, gene discovery, and a better understanding of the genetic basis of complex traits. ...
Currently, significant improvements are being made in the field of sequencing technology, as exemplified by the arrival of third-generation sequencers, such as those manufactured by ONT. Notably, these sequencers are anticipated to be compatible with mobile devices, which could potentially facilitate ...
We have currently entered a genomic era of cancer research which may soon lead to a genomic era of cancer treatment. Patient DNA sequencing information may... CD Heinen - 《Dna Repair》 被引量: 12发表: 2016年 Cervical Cancer Screening: From Molecular Basis to Diagnostic Practice, Going throug...
Next-generation sequencing (NGS) has transformed genomic research by decreasing the cost of sequencing. However, whole-genome sequencing is still costly and complex for diagnostics purposes. In the clinical space, targeted sequencing has the advantage of allowing researchers to focus on specific genes ...
This review commemorates the 40th anniversary of DNA sequencing, a period in which we have already witnessed multiple technological revolutions and a growth in scale from a few kilobases to the first human genome, and now to millions of human and a myriad of other genomes. DNA sequencing has ...
With the highly-developed commercial high-throughput sequencing platforms, each laboratory has the opportunity to explore this research field. Therefore, in this paper, we have focused on commercially-popular high-throughput sequencing techniques and the ways in which they have been applied over the ...