DNA损伤与修复 PPT课件 第六章DNA损伤与修复DNAdamageandrepair 分子生物学研究中心 第一节DNA损伤的原因及后果 电离辐射烷化剂 可见光 复制错误 核苷类似物 H+ mC P/ 8-oxoG U P DNA损伤类型 •碱基脱落•碱基修饰&去氨基化 •化学修饰•光损伤 •链内交联•DNA-蛋白质交联•DNA链断裂 •DNA...
1、第六章 DNA损伤与修复 DNA damage and repair,分子生物学研究中心,第一节 DNA损伤的原因及后果,电离辐射,可见光,氧自由基,H+,烷化剂,8-oxoG,P/P,复制错误,核苷类似物,mC,U,DNA 损伤类型,碱基脱落 碱基修饰 & 去氨基化,化学修饰 光损伤,链内交联 DNA-蛋白质 交联 DNA链断裂,DNA 重组,缺失碱基位点...
连接 MutH 真核生物的碱基错配修复 recombination repairing 同源重组homologous recombination non-homologous end joining Recombination 非同源末端连接的重组修复 存在一定的错误 第五章 DNA损伤与修复 DNA Damage and Repair 作为一种能决定生命状态存在和延续的生物大分子,DNA在遗传过程中必需保持高度的精确性和完整性...
1、 DNA损伤与修复 DNA DAMAGE AND REPAIR Deoxyribonucleic Acid (DNA)NNNHNNH2lAdenine NHNNHNONH2lGuanineConstitution of DNAuracilNHNHOONNHNH2OcytosineNHNHOOthymine ribose (deoxyribose) + base ribose (deoxyribose) + base C-N bond C-N bond(OH)(OH)Nucleotide(核苷酸)(核苷酸) O-POO-NNNNNH2OHHO...
Expression of DNA repair genes may be reduced by inherited germ line mutations or genetic polymorphisms, or by epigenetic alterations or mutations in somatic cells, and these reductions may substantially increase the risk of cancer. Overall, about 30% of cancers are considered to be familial (large...
Ishikawa T, Zhang S S, Qin X, et al. DNA repair and cancer: lessons from mutant mouse models [ J ]. Cancer Sci, 2004, 95(2) :112-117.Ishikawa T,Zhang S S,Qin X,et al.DNA repair and cancer: lessons from mutant mouse models. Cancer Science . 2004...
Secrets of DNA-PKcs beyond DNA repair Article Open access 23 July 2024 RHNO1: at the crossroads of DNA replication stress, DNA repair, and cancer Article 06 August 2024 References Singleton, M. R., Dillingham, M. S. & Wigley, D. B. Structure and mechanism of helicases and nuclei...
He also explained the molecular mechanisms behind the photoreactivation process, which is type of light dependent DNA repair mechanism. All these contributions helped us to understand the nature of some diseases like cancer and they helped to develop new therapies against many diseases including cancer...
This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages that are embedded in mill...
Model:Carcinogen-inducedcoloncancerinrats. EarlyCarcinogenesis:DNAdamagetocells,andassociatedrepairandcelldeath(apoptosis) Ifnotrepairedorremoved Mutation Coloncancer SomeBackground Weareespeciallyinterestedinanatomicaleffects Regionsofthecolon,e.g.,proximal(front)anddistal(back) ...