DNA损伤与修复 PPT课件 第六章DNA损伤与修复DNAdamageandrepair 分子生物学研究中心 第一节DNA损伤的原因及后果 电离辐射烷化剂 可见光 复制错误 核苷类似物 H+ mC P/ 8-oxoG U P DNA损伤类型 •碱基脱落•碱基修饰&去氨基化 •化学修饰•光损伤 •链内交联•DNA-蛋白质交联•DNA链断裂 •DNA...
1、第六章 DNA损伤与修复 DNA damage and repair,分子生物学研究中心,第一节 DNA损伤的原因及后果,电离辐射,可见光,氧自由基,H+,烷化剂,8-oxoG,P/P,复制错误,核苷类似物,mC,U,DNA 损伤类型,碱基脱落 碱基修饰 & 去氨基化,化学修饰 光损伤,链内交联 DNA-蛋白质 交联 DNA链断裂,DNA 重组,缺失碱基位点...
基因突变与DNA损失修复PPT课件.ppt,三类 (4) 化学诱变剂(chemical Mutagens) 基碱类似物(Base analogs) 基碱修饰剂(Base modifying agents) 嵌入剂 (Intercalating agents) ① 碱基类似物 其分子结构极其相似于DNA分子中的正常碱 基,故可以结合进复制的DNA链中去
分子生物学 04 DNA replication.ppt,Chapter 04: DNA Replication 生物体的遗传信息以密码的形式编码在DNA分子上,表现为特定的核苷酸排列顺序; 遗传信息通过DNA的复制由亲代传递给子代; DNA双螺旋模型的提出是DNA复制的理论基础。 1 overview of DNA replication 1.1 sem
解读解读凯恩斯的实验结果可得到两个重要的结论乳糖可诱使,突变种持续产生,而不是因为饥饿所导致,乳糖诱使细菌产生特定方向的突变,也就是乳糖只会诱使大肠杆菌的基因产生突变,而不影响其他的基因,三,突变体的分离与分析,一,突变体的分离,分子生物学
** Many lesions can still escape DNA repair and are Many lesions can still escape DNA repair and are present at the time of DNA replication present at the time of DNA replication ** During DNA replication During DNA replication -- unrepaired damage can unrepaired damage can block the major...
DNA Replication, Recombination, and Repair:DNA复制,重组,修复 热度: dna replication timing复制时机 热度: 2.1.基本概念 2.2.复制起点与方向 2.3.Semi-ConservationReplication 2.4.复制的方式 2.5.线状DNA的复制 2.6.DNA复制的基因与酶类体系 2.7.DNA复制速率及拷贝数的调控 ...
MutationsarisenotonlyfromerrorsinreplicationbutalsofromdamagetotheDNA.•Somedamageiscaused,asweshallsee,byenvironmentalfactors,suchasradiationandsocalledmutagens（诱变剂）,whicharechemicalagentsthatincreasetherateofmutation •ButDNAalsoundergoesspontaneousdamagedependsonanaqueousenvironment ①电离辐射 Ionizing（x-...
polymeraseε DNA polymeraseβ DNA polymeraseγ Probable role originate DNA replication DNA replication: leading strand lagging strand Unknown, structure similar toδ DNA repair Replication of mtDNA New nucleosomes are assembled to DNA from a mixture of old and newly synthesized histones after the fork...
10、) a large multienzyme compound scans the DNA strand for anomalities upon detection a nuclease cuts the strand on both sides of the damage DNA helicase removes the oligonucleotide the gap is repaired by DNA polymerase and DNA ligase enzymesMismatch repairDuring the replication of DNA, wrong ba...