DNA损伤与修复 PPT课件 第六章DNA损伤与修复DNAdamageandrepair 分子生物学研究中心 第一节DNA损伤的原因及后果 电离辐射烷化剂 可见光 复制错误 核苷类似物 H+ mC P/ 8-oxoG U P DNA损伤类型 •碱基脱落•碱基修饰&去氨基化 •化学修饰•光损伤 •链内交联•DNA-蛋白质交联•DNA链断裂 •DNA...
第四章 DNA的复制、突变、损伤和修复第一节 DNA的复制一、DNA复制的一般特征 二、原核生物的DNA复制 三、真核生物DNA复制 四、线粒体DNA复制 五、噬菌体和病毒DNA的复制 DNAreplication,mutation,injuryandrepa ir (一)单链环状DNA的复制过程单链环状DNA以滚环复制方式进行,如大肠杆菌噬菌 体ΦX174、M13、G等...
(7) SOS 修复 Irradiation of bacteria before virus infection enhanced repair of damaged viral genes but led to mutations. SOS 修复诱导 DNA 聚合酶活性 LexA (一种DNA结合抑制蛋白), umuC 和 umuD, 编码 DNA聚合酶活性,允许复制跨过 损伤位点, 常插入一个或几个 A碱基. SOS 修复 DNA复制不很严格,新...
1.DNAreplication2.Chemicaldamagetothegenematerial3.InsertionscausedbyDNAelements Lifeandbiodiversitydependonahappybalancebetweenmutationanditsrepair.牛牛文库文档分享 突变体(mutant)：携带突变的生物个体或群体或株系突变基因(mutantgene):存在突变位点的基因野生型基因（wildtypegene）：表示方法表现型Arg+Arg基因型arg...
1、第六章 DNA损伤与修复 DNA damage and repair,分子生物学研究中心,第一节 DNA损伤的原因及后果,电离辐射,可见光,氧自由基,H+,烷化剂,8-oxoG,P/P,复制错误,核苷类似物,mC,U,DNA 损伤类型,碱基脱落 碱基修饰 & 去氨基化,化学修饰 光损伤,链内交联 DNA-蛋白质 交联 DNA链断裂,DNA 重组,缺失碱基位点...
DNA replicase is a DNA-synthesizing enzyme required specifically for replication. Repair of damaged DNA can take place by repair synthesis, when a strand that has been damaged is excised and replaced by the synthesis of a new stretch. It can also take place by recombination reactions, when ...
分子生物学 04 DNA replication.ppt,Chapter 04: DNA Replication 生物体的遗传信息以密码的形式编码在DNA分子上,表现为特定的核苷酸排列顺序; 遗传信息通过DNA的复制由亲代传递给子代; DNA双螺旋模型的提出是DNA复制的理论基础。 1 overview of DNA replication 1.1 sem
1 + 3 2 戊糖 糖苷键 Basepair 氢键 LocationofDNA NuclearDNA Chromatin/Chromosome MitochondrialDNA Histone?DNAdamage •ThecauseofDNAdamage•ThepatternofDNAdamage ThecauseofDNAdamage •Direct Radiation,UV,Chemicalexposure •Indirect Cellularmetabolism,replicationerror ThepatternofDNAdamage •Oxidation...
MutationsarisenotonlyfromerrorsinreplicationbutalsofromdamagetotheDNA.•Somedamageiscaused,asweshallsee,byenvironmentalfactors,suchasradiationandsocalledmutagens（诱变剂）,whicharechemicalagentsthatincreasetherateofmutation •ButDNAalsoundergoesspontaneousdamagedependsonanaqueousenvironment ①电离辐射 Ionizing（x-...
DNAReplication,Recombination,andRepairGuo-MinLi(李国民),Ph.D.ProfessorJamesGardnerEndowedChairinCancerResearchUniversityofKentuckyCollegeofMedicineSelfintroduction•DNArepair,genomeinstability,andcancer•TrinucleotiderepeatinstabilityandneurodegenerativediseasdesResearchInterest•Hypermutabilityandmismatchrepairdeficiencyin...