DNAdamageandrepair DNA（脱氧核糖核酸）Adenine Thymine Guanine Cytosine 5 4 1 + 3 2 戊糖 糖苷键 Basepair 氢键 LocationofDNA NuclearDNA Chromatin/Chromosome MitochondrialDNA Histone?DNAdamage •ThecauseofDNAdamage•ThepatternofDNAdamage ThecauseofDNAdamage •Direct Radiation,UV,Chemicalexposure •...
10DNA损伤与修复.ppt,Advanced Molecular Biology For Graduate Students Dr. Zhaohui Gong Tel:87600754 gongzhaohui @nbu.edu.cn Chapter 3: Biosynthesis and Recombination of Genomic DNA/RNA Learning Objectives Common mechanism and different characteristics of
1、 DNA损伤与修复 DNA DAMAGE AND REPAIR Deoxyribonucleic Acid (DNA)NNNHNNH2lAdenine NHNNHNONH2lGuanineConstitution of DNAuracilNHNHOONNHNH2OcytosineNHNHOOthymine ribose (deoxyribose) + base ribose (deoxyribose) + base C-N bond C-N bond(OH)(OH)Nucleotide(核苷酸)(核苷酸) O-POO-NNNNNH2OHHO...
Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance 热度: Therapeutic modulation of dna damage and repair mechanisms in blood cells 热度: Direct detection and quantification of abasic sites for in vivo studies of DNA damage and repa...
DNA的生物合成和损伤修复DNABiosynthesisandDNADamageRepair课件.ppt,Section Five DNA Replication in Mitochondria and Phages mtDNA replicates in D-loops. 2.Phage’s circular DNA replicates in rolling circle. * * Section Six The Repair of DNA Damage * * 1. Ph
Chapter5 DNAdamage,repairandmutation 第一节DNA损伤 一、自发性损伤（spontaneousmutations）1、DNA复制错误校正后的错配率仍约在10-10左右2、互变异构(烯醇式-酮式结构互变)3、自发性的化学变化脱嘌呤和脱嘧啶脱氨（基）(deamination)作用 （1）脱嘌呤和脱嘧啶 •糖苷键断裂,嘌呤和嘧啶从DNA链的核糖磷酸骨架...
DNA损伤修复功能异常是肿瘤发生发展的重要特点之一,突变与癌症的发生均包含细胞DNA损伤过程。人类细胞中的DNA每天都会由于外部(外源)和内部(内源)的代谢进程而遭受成千上百次损伤。细胞基因组的改变可能导致DNA转录过程出现错误,进而通过翻译过程影响到信号转导和细胞功能必需的蛋白质。如果有丝分裂之前这些基因组突变尚...
DNADamageandRepair DNADamage •DNALesion（DNA损害）:AnalterationtothenormalchemicalorphysicalstructureofDNA OxidativeDamage（氧化损伤）Alkylation（烷基化）BulkyAdducts（加合物）•SomeofthenitrogenandcarbonatomsinDNAaresubjectedtochemicalreaction.•Agentssuchaschemicalsandradiationcancausechangestothesepositions ...
1.DNAreplication2.Chemicaldamagetothegenematerial3.InsertionscausedbyDNAelements Lifeandbiodiversitydependonahappybalancebetweenmutationanditsrepair.牛牛文库文档分享 突变体(mutant)：携带突变的生物个体或群体或株系突变基因(mutantgene):存在突变位点的基因野生型基因（wildtypegene）：表示方法表现型Arg+Arg基因型arg...
DNAdamage,repair,andrecombination F1MutagenesisF2DNAdamageF3DNArepairF4Recombination F1Mutagenesis 1.Mutation MutationareheritablepermanentchangesinthebasesequenceofDNA.1.1Pointmutation:isthesimplestmutation-asinglebasechange.Transition:purineorpyrimidineisreplacedbytheother AGTC F1Mutagenesis 1Mutation Transversion:a...