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DNA损伤与修复机制 | DNA damage and repair DNA损伤修复功能异常是肿瘤发生发展的重要特点之一,突变与癌症的发生均包含细胞DNA损伤过程。人类细胞中的DNA每天都会由于外部(外源)和内部(内源)的代谢进程而遭受成千上百次损伤。细胞基因组的改变可能导致DNA转录过程出现错误,进而通过翻译过程影响到信号转导和细胞功能必需...
[19] Chang, H. H. Y., Pannunzio, N. R., Adachi, N., and Lieber, M. R. (2017). Non-homologous DNA end joining and alternative pathways to double-strand break repair [J]. Nat. Rev. Mol. Cell Biol. 18, 495–506. [20] Zhou BBS, Elledge SJ. The DNA damage response: putting...
DNA is the basic unit of inheritance that maintains the integrity and function of living organisms. However, it is constantly exposed to damaging agents which can cause DNA damage. Additionally, errors can occur duringDNA replicationand repair processes, leading to harmful mutations. DNA Damage and ...
DNA damage and repair: from molecular mechanisms to health implications. Antioxid. Redox Signal 10 (5), 891-937.Altieri, F., Grillo, C., Maceroni, M. and Chichiarelli, S. (2008) DNA Damage and Repair: From Molecular Mechan- isms to Health Implications. Antioxidants & Redox Signaling, ...
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Chapter5 DNAdamage,repairandmutation 第一节DNA损伤 一、自发性损伤（spontaneousmutations）1、DNA复制错误校正后的错配率仍约在10-10左右2、互变异构(烯醇式-酮式结构互变)3、自发性的化学变化脱嘌呤和脱嘧啶脱氨（基）(deamination)作用 （1）脱嘌呤和脱嘧啶 •糖苷键断裂,嘌呤和嘧啶从DNA链的核糖磷酸骨架...
[35]Yan S, Sorrell M, Berman Z. Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress[J]. Cell Mol Life Sci, 2014, 71(20): 3951-3967. DOI: 10.1007/s00018-014-1666-4. [3...
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2022年7月13日,罗切斯特大学Vera Gorbunova教授和浙江大学医学院赵阳研究员及其同事受邀在Nature Reviews Immunology上发表了题为“DNA damage and repair in age-related inflammation”的综述文章。作者首先介绍了DNA损伤造成炎症的机制,即通过细胞质核酸感受激活先天免疫通路。随后总结了炎症反应在几中重要的衰老相关事件中...