Such oligomers are not cleaved by the DNA repair enzyme, UDG, which cleaves the glycosylic bond in dU but not in dT nor in dC nucleosides in single stranded and double stranded DNA. Differential binding of oligomers containing carbadU, 4-thiodU, and dU residues to wild type and mutant ...
JERUSALEM, April 5 (Xinhua) -- Israeli researchers discovered a mechanism responsible for the rapid repair of broken DNA, the northern Israel Institute of Technology, or Technion, said on Tuesday. The discovery, included in a new study published in the journal Nature Communications, may have impl...
例句 释义: 全部 更多例句筛选 1. Some DNA repair mechanism can even induce mutagenesis so that the offspring may adapt to the new environment. DNA修复反应还会主动引入突变,以期产生适应新环境的后代。 www.say666.com© 2025 Microsoft 隐私声明和 Cookie 法律声明 广告 帮助 反馈...
Polymorphisms of DNA repair genes including the BER genes may also increase the cancer risk and thus determine the outcome of disease for patients [193,451,456,461,478–484]. On the other hand, the meta-analysis of the data indicated that it is unlikely that DNA repair gene polymorphisms ...
Accurate chromosomal DNA replication is essential to maintain genomic stability. Genetic evidence suggests that certain repetitive sequences impair replication, yet the underlying mechanism is poorly defined. Replication could be directly inhibited by th
The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers the establishment of megabase-sized, chromatin domains decorated with phosphorylated histone H2AX (γH2AX), which act as seeds for the forma...
Furthermore, the time of high functionality increases, and consequently slows down the ageing process, if the DNA repair mechanism itself is vulnerable to DNA damages.Although counterintuitive at first glance, a fragile repair mechanism allows for a faster removal of compromised cells, thus freeing ...
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Cadmium inhibits mismatch repair by blocking the ATPase activity of the MSH2–MSH6 complex Cadmium (Cd2+) is a known carcinogen that inactivates the DNA mismatch repair (MMR) pathway. In this study, we have tested the effect of Cd2+ exposure on t... B Sreeparna,FR Hernan - 《Nucleic ...
Repair of double-strand DNA breaks by homologous recombination can be carried out in bacteria by RecBCD, AddAB and AdnAB. Here, Dale Wigley discusses recent insights into how these complexes mediate repair, as well as their evolution. In bacteria, the pr