DNA repair pathways and mechanisms. In: Mathews L, Cabarcas S, Hurt E, editors. DNA repair of cancer stem cells. Dordrecht: Springer; 2013. p. 19-32.Dexheimer, T.S., 2013. DNA repair pathways and mechanisms. In: Mathews, L.A., Cabarcas, S.M., Hurt, E. (Eds.), DNA Repair...
Mitochondrial DNA repair pathwaysMitochondrial DNA repair pathwaysdoi:10.1016/S0921-8777(99)00025-7MitochondrialDNArepairpathwaysBaseexcisionrepairNucleotideexcisionrepairDNA repair mechanisms are fairly well characterized for nuclear DNA while knowledge regarding the repair mechanisms operable in mitochondria is li...
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Bacteria are continuously exposed to numerous endogenous and exogenous DNA-damaging agents. To maintain genome integrity and ensure cell survival, bacteria have evolved several DNA repair pathways to correct different types of DNA damage and non-canonical bases, including strand breaks, nucleotide modifica...
Helicase-dependent DNA damage response and repair mechanisms help cells to cope with endogenous or exogenous stress to prevent chromosomal instability and maintain cellular homeostasis. Inactivating mutations in DNA helicase genes are linked to genetic disorders that are frequently associated with various can...
30.Vogel U, Dybdahl M, Frentz G, Nexø BA. 2000. DNA repair capacity: inconsistency between effect of over-expression of five NER genes and the correlation to mRNA levels in primary lymphocytes. Mutation Research/DNA Repair. 461(3):197-210.31.Hanawalt PC. 2002. Subpathways of nucleotide...
1、chapterDNA损伤及修复How to minimize damage to your DNAAvoidAvoidAvoidAvoidAvoidAvoidchemical warfareprocessed foodsthe highwayssunlightaerobic activitieswaterBut if all these precautions fail, our cells havemultiple DNA repair pathways to undo the damage!DNADNA损伤损伤(DNA damageDNA damage) DNADNA修复...
[1] Sancar A., Lindsey-Boltz L.A.,et al. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints [J]. Annu. Rev. Biochem. 2004; 73: 39-85. [2] Lindahl T. Instability and decay of the primary structure of DNA [J]. Nature. 1993; 362: 709-715. ...
DNA Repair Pathways Abstract Genomic integrity of organisms is maintained by the action of DNA repair pathways. Each repair pathway is directed to recognize and remove specific types of damaged or mispaired bases. Usually, repair pathways are highly conserved among eukaryotes and often show a ...
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. The specificity of MMR is primarily for base-base mismatches and insertion/deletion mispairs generated during DNA replication and r