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To overcome the harmful effects of DNA damage, cells have various systems such as DNA repair mechanisms, damage tolerance pathways, cell cycle checkpoints, and cell death pathways. These systems work together to repair or tolerate DNA damage, ensuring the overall survival and functionality of cells...
1、chapterDNA损伤及修复How to minimize damage to your DNAAvoidAvoidAvoidAvoidAvoidAvoidchemical warfareprocessed foodsthe highwayssunlightaerobic activitieswaterBut if all these precautions fail, our cells havemultiple DNA repair pathways to undo the damage!DNADNA损伤损伤(DNA damageDNA damage) DNADNA修复...
Alternative DNA structure-forming sequences can stimulate mutagenesis and are enriched at mutation hotspots in human cancer genomes, implicating them in disease etiology. However, the mechanisms involved are not well characterized. Here, we discover that
2. 什么导致DNA损伤？3. DNA损伤的类型 3.1 内源性DNA损伤3.2 外源性DNA损伤 4. DNA损伤与DNA变异 5. DNA损伤应答（DDR）途径 5.1 DNA修复机制5.2 细胞周期停滞与细胞凋亡 6. DNA损伤与疾病 7. 与DNA损伤修复相关的重组蛋白 1. 什么是DNA损伤？DNA损伤是指任何偏离其原始双螺旋结构的改变。所有细胞...
Mitochondrial DNA repair pathwaysMitochondrial DNA repair pathwaysBase excision repairNucleotide excision repairDNA repair mechanisms are fairly well characterized for nuclear DNA while knowledge regarding the repair mechanisms operable in mitochondria is limited. Several lines of evidence suggest that mitochondria...
DNA Repair Mechanisms 1978, Pages 413-416PATHWAYS OF DNA REPAIR IN YEAST1 Author links open overlay panelLouise Prakash, Satya PrakashShow more Share Cite https://doi.org/10.1016/B978-0-12-322650-1.50079-5Get rights and content ABSTRACT The RAD1 excision-repair pathway of yeast consists of ...
1. CRISPR Induces DNA Repair Pathways: NHEJ, HDR, and Beyond CRISPR的工作原理是锁定基因组中的一个精确位置,然后切断两条DNA链,在那个特定的位置产生双链断裂(DSB)。由于细胞无法在DNA被切断的情况下存活很长时间,所以一旦DNA断裂,它们的警报就会响起。修复断裂的步骤很快就开始了。 DNA断裂在许多生物体中是...