We demonstrate a novel cascade of learning-induced molecular events in discrete neuronal clusters undergoing dsDNA damage and TLR9-mediated repair, resulting in their recruitment to memory circuits. With compromised TLR9 function, this fundamental memory mechanism becomes a gateway to genomic instability ...
A. DNA double-strand break repair-pathway choice in somatic mammalian cells. Nat. Rev. Mol. Cell Biol. 20, 698–714 (2019). Article CAS PubMed PubMed Central Google Scholar den Hollander, A. I. et al. Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP...
A sophisticated mechanism governs Pol ζ activity in response to replication stress Chun Li Shuchen Fan Xialu Li Nature Communications(2024) Molecular mechanisms of DNA lesion and repair during antibody somatic hypermutation Qian Hao Jinfeng Li ...
PARP1 is recruited to telomeres to repair internal telomere DNA breaks and base lesions15,16 and can promote telomere fusions via the alternative end-joining mechanism17. Furthermore, telomeric DNA terminates with a single-stranded 3′ overhang and recessed 5′ end, a potent trigger of PARP1 ...
Many mechanisms such as the breakage-fusion-bridge (BFB) cycle, micronucleation, chromothripsis, and cell death-induced DNA fragmentation have been proposed to explain the biogenesis of eccDNA and may involve DNA breakage and repair [38, 56,57,58,59,60,61]. The BFB cycle caused by ...
repair, and hence decided to replace the track with a MIDI‑triggered part. Alternatively, you might just want to layer a programmed instrument alongside an existing live track, or export the notes to a score editor to generate sheet music. In short, this is a nice little function, ...
Damage and Repair of DNA: Being the carrier of genetic information, the cellular DNA must be replicated (duplicated), maintained, and passed down to the daughter cells accurately. In general, the accuracy of replication is extremely high. However, there do occur replication errors. It is estimat...
评估和控制药物中的DNA活性(致突变)杂质以限制潜在的致癌风险附录英文原文.pdf,INTERNATIONAL COUNCIL FOR HARMONISATION OF TECHNICAL REQUIREMENTS FOR PHARMACEUTICALS FOR HUMAN USE (ICH) ICH HARMONISED GUIDELINE APPLICATION OF THE PRINCIPLES OF THE ICH M7 GUI
5. The DNA fragments resulting from this shattering event are re-ligated by error-prone repair processes, with some of the fragments being lost. The outcome is a highly rearranged derivative chromosome, with oscillations between two or three copy number states6. Conversely, the local rearrangements...
Here we propose that protein-mediated DNA loop extrusion may promote fast and efficient synapsis in cells. We emphasize that loop extrusion can be a preemptive mechanism facilitating synapsis, in contrast to the reactive recruitment of DSB repair machinery after the DSB has occurred, where DSB ends...