DNA is the basic unit of inheritance that maintains the integrity and function of living organisms. However, it is constantly exposed to damaging agents which can cause DNA damage. Additionally, errors can occur duringDNA replicationand repair processes, leading to harmful mutations. DNA Damage and ...
Chromatin looping induced by damage and repair We suggest that de novo DNA methylation at the site of DSB repair stabilizes the H3K9m3 mark, which alters the chromatin structure of the entire GFP gene. To map specific domains modified by DNA damage and repair, we examined the structure of chr...
DNA damage and repair Genomic instability Senescence This article is cited by Intestinal Microbiota and Aging in People with HIV—What We Know and What We Don’t S. M. Shamsul Islam Shalini Singh Mohamed Abdel-Mohsen Current HIV/AIDS Reports(2025) ...
Genetics & Pharmaceutical,Population Health Management, Nutrition and Phytochemistry,Precision Cancer Medicine,Prostate Cancer: Monitoring vs Treatment,RNA Biology, Cancer and Therapeutics,tumor microenvironment, taggedCancer,DNA damage,DNA repair,gender,mutation,sexon April 2, 2019|Leave a Comment » Gende...
A DNA Damage Checkpoint is a mechanism that allows cells to pause cell division in order to repair damaged DNA and prevent the transmission of broken chromosomes to daughter cells. AI generated definition based on: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging,...
damage to the genetic materials is a major threat to all organisms. In order to counteract these threats, cells has evolved many methods to overcome and rectify different types DNA damages. All these methods are collectively termed asDNA REPAIRmechanisms. Similar to DNA replication, transcription an...
Human DNA topoisomerase I is an essential enzyme involved in resolving the torsional stress associated with DNA replication, transcription, and chromatin c... JB Leppard,JJ Champoux - 《Chromosoma》 被引量: 275发表: 2005年 The DNA damage response--repair or despair? It has been known for over...
DNA repair is a double-edged sword in stem cells. It protects normal stem cells in both embryonic and adult tissues from genetic damage, thus allowing perpetuation of intact genomes into new tissues. Fast and efficient DNA repair mechanisms have evolved in normal stem and progenitor cells. Upon...
& Adar, S. Cisplatin DNA damage and repair maps of the human genome at single-nucleotide resolution. Proc. Natl Acad. Sci. USA 113, 11507–11512 (2016). Article CAS Google Scholar Zhong, L. et al. Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis. Cell Discov. 6,...
Ataxia Telangiectasia (A-T) is neurodegenerative syndrome caused by inherited mutations inactivating the ATM kinase, a master regulator of the DNA damage response (DDR). What makes neurons vulnerable to ATM loss remains unclear. In this study we assessed