The mucosal epithelium is a common target of damage by chronic bacterial infections and the accompanying toxins, and most cancers originate from this tissue. We investigated whether colibactin, a potent genotoxin1 associated with certain strains of Esche
we treated the MB cells isolated from theNestin-Cre p53−/−Xrcc4−/−mouse tumors with inhibitors of HR (B02 or Ri1, RAD51 inhibitors) and/or Alt-EJ (olaparib, PARP inhibitor) or induced DNA damage using topotecan (a topoisomerase 1 inhibitor), ...
After eclosion, the larvae mine into leaves, causing serious damage to the leaves (Heppner 1993). After its occurrence in one region, CLM spreads across the whole country within 1 year, as was the case in Spain in 1993 (Urbaneja et al 2000). It is recently suggested that CLM may become...
Nanopore sequencing, instead of using a sequencing-by-synthesis method to detect signal for the amplified DNA fragment population, is able to directly detect DNA or RNA translocation through a voltage-biased nanopore sensor, enabling rapid long-read sequencing and single-base, single-molecule sensitivi...
Analysis on feeding habits of wild red deer in forest area and its damage to young forest[J]. Chinese Journal of Zoology, 1989, 24(3):34-36. [9]Stewart D. Analysis of plant epidermis in faeces :a technique for studying the food preferences of grazing herbivores[J]. The Journal of ...
评估和控制药物中的DNA活性(致突变)杂质以限制潜在的致癌风险附录英文原文.pdf,INTERNATIONAL COUNCIL FOR HARMONISATION OF TECHNICAL REQUIREMENTS FOR PHARMACEUTICALS FOR HUMAN USE (ICH) ICH HARMONISED GUIDELINE APPLICATION OF THE PRINCIPLES OF THE ICH M7 GUI
3. GENERAL PRINCIPLES The focus of this guideline is on DNA reactive substances that have a potential to directly cause DNA damage when present at low levels leading to mutations and therefore, potentially causing cancer. This type of mutagenic carcinogen is usually detected in a bacterial reverse...
cytotoxic drugs; DNA damage response; immunotherapy; programmed death ligand-1 (PD-L1) 1. Introduction Surgery, chemotherapy, and radiation therapy constitute the main approaches to cancer treatment. One alternative way of targeting cancer concentrates on boosting the patient’s immune system so that ...
Review Reports Versions Notes Abstract DNA damage response (DDR) is critical to ensure genome stability, and defects in this signaling pathway are highly associated with carcinogenesis and tumor progression. Nevertheless, this also provides therapeutic opportunities, as cells with defective DDR signaling ...
https://ibiochips.com/?gclid=Cj0KCQjwuLPnBRDjARIsACDzGL0wb6u79VHHkftodfApMYs-oxI-5cOZIBUaELdmd2wDOIk3W0OQg2caAqMyEALw_wcB 4.4.2 Targeted Single-Cell Solutions for High Impact Applications – Mission Bio’s Tapestri® Platform is the only technology that provides single-cell targeted DNA ...