2777Accesses 8Altmetric Metrics Abstract To avoid innate sensing and immune control, human immunodeficiency virus type 1 (HIV-1) has to prevent the accumulation of viral complementary DNA species. Here, we show that the late HIV-1 accessory protein Vpu hijacks DNA repair mechanisms to promote deg...
The spike protein hijacks the DNA damage repair mechanism. The DNA damage repair mechanism is what mitigates deleterious mutations. Deleterious mutations cause tumors. The vaccines don’t elicit antibodies to the entire virus, may blunt CD4 T cell response & efficacy wanes to less than...
Increased PCR success—Robust amplification of GC-rich targets, DNA of suboptimal purity, and long sequences Enabled automation—High specificity and benchtop stability for 24 hours after reaction setup, enabled by Invitrogen Platinum hot-start technology ...
Cell Host Microbe 27(5):841–848. Resources for Platinum SuperFi II DNA polymerase Flyers Platinum SuperFi II DNA Polymerase Improve microbiome studies Manuals/Protocols Protocol: Site-directed mutagenesis using the GeneArt Gibson Assembly HiFi Cloning Kit Platinum Sup...
DNA ligase IV: homologous recombination repair and important in immune cell development and other activities critical to a normal cell. NAD+dependent DNA ligases: Bacterial DNA ligases are NAD+dependent ligases. They are also present in some mimivirus and entomovirus. While some bacteria, archaea,...
DNA repair and sensitizes cancer cells to irradiation treatment. In contrast, depletion of RIG-I renders cells resistant to irradiation in vitro and in vivo. In addition, this mechanism suggests a protective role of RIG-I in hindering retrovirus integration into the host genome by suppressing the...
DNA microarrays are solid supports, usually of glass or silicon, upon which DNA is attached in an organized, pre-determined grid fashion.
they evolved different strategies. One such strategies are the regulation through epigenetic mechanism. Although adaptive phenotypic variation is mainly regulated by genetic architecture driven by mutation, drift and migration however, it accounts for a small proportion of the total phenotypic variation obse...
The DNA sensor cGAS detects cytosolic DNA and instigates type I interferon (IFN) expression. Recent studies find that cGAS also localizes in the nucleus and binds the chromatin. Despite the mechanism controlling nuclear cGAS activation is well elucidated
Recombinant DNA technology refers to the joining together of DNA molecules from two different species. Recombinant DNA in a living organism was first achieved in 1973 by Herbert Boyer.