人类DNA损伤反应阵列(27个靶点),Human DNA Damage Response Array (27 Targets)产品背景资料查看产品说明书。 产品描述 人DNA 损伤反应阵列是 Assay Genie 的抗体阵列,是一种高质量多重检测,可检测 27 个靶标,包括 ABL1、APEX1、ATR、BRCA1、BRCA2、CCNB1、CDC25A、CDK1、CDK7、CDKN1A| CHEK1、CHEK2、DDI...
2A complex DNA damage response (DDR) network has been evolved to maintain the integrity and fidelity of genomic DNA. These DDR networks include DNA repair pathways themselves and a repertoire of regulatory signaling events which are closely related to other cellular processes such as cell cycle...
Heterochromatin and the DNA damage response: the need to relax. Biochem. Cell Biol. 89, 45–60 (2011). Article CAS PubMed Google Scholar Noon, A.T. et al. 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nat. Cell ...
(abasic site in DNA); ATM: Ataxia telangiectasia mutated protein kinase; BRCA1: Breast cancer type 1 susceptibility protein; c- Abl: Abelson non-receptor tyrosine kinase; DDR: DNA damage response; fALS: Familial ALS; iPSC: induced pluripotent stem cell; LCM: Laser capture microdissection; OHdG...
TPP1于2004年由3个独立实验发现,在端粒保护蛋白复合体的形成过程中起关键作用,并可通过其寡核苷酸结合域(OB fold)与端粒酶结合,调节端粒酶活性.然而,TPP1在保护端粒末端不被识别为断裂的双链DNA(Double Strand Breaks, DSBs),抑制DNA损伤反应(DNA Damage Response, DDR)及其启动的信号转导作用通路,维持染色体稳定性...
-Nucleostain-DNA Damage Quantification Kit-AP Site Counting-是一种可以通过使用ARP将DNA生物素化并固定在96孔微板上,可以简单地定量样品DNA中的AP 位点的试剂盒。 该试剂盒包含具有与AP位点的标准DNA,并且可以使用HRP标记的链霉亲和素通过生物素检测方法对AP位点进行定量。 使用方法请看实验例。 *冷藏保存中或...
1、【Nature, IF=69.5】RNA m6A methylation regulates the ultravioletinduced DNA damage response. 本篇文章报道了m6A甲基化修饰在紫外线所致DNA损伤反应中的新功能。在紫外线所致的DNA损伤早期修复过程中,m6A甲基化修饰的RNA迅速在DNA损伤位点聚集,促进损伤的修复。该过程发生在许多poly(A)+转录本上,并受到METTL3...
www.nature.com/scientificreports OPEN The γH2AX DNA damage assay from a drop of blood received: 31 July 2015 accepted: 17 February 2016 Published: 04 March 2016 Daniel Heylmann & Bernd Kaina DNA double-strand breaks (DSB) and blocked replication forks activate the DNA damage response (...
damage response (DDR), and SUMOylated NPM1 impacts the assembly of the BRCA1 complex. Knockdown of hCINAP also sensitizes a patient-derived xenograft (PDX) mouse model to chemotherapy. In clinical AML samples, low hCINAP expression is associated with a higher overall survival rate in patients....
两微升的待测样品或阳性对照(Minesol (Roc) SPF 60)分别涂抹于四孔组织模型的角质层表面,两个未处理过的阴性对照同时进行平行实验,同一样品处理的两个复孔在300 毫焦/平方厘米的UVB光下照射(太阳模拟器 BIOSUN),另两个复孔避光放置于室温作为未照射对照组,照射后组织模型直接进行组织学鉴定。