The DNA repair and DNA damage response (DDR) pathway is frequently disrupted in cancer and is one of the hallmarks of cancer. Germline and/or somatic mutations in critical DNA repair/DDR genes cause predisposition to cancer and higher mutational burden in cancers, respectively. Synthetic lethality...
DNA Damage, Repair, and Cancer Metabolism. Front Oncol. 2018 Feb 5;8:15. Adrián Campos, et al. Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins. Int J Mol Sci. 2020 Jan 10;21(2):446. Markus Christmann, et al. Transcriptional ...
Hence, damage occurring in stem cells can be transmitted both horizontally (to other stem cells) and vertically (to differentiating cells). To study the DNA damage response (DDR) and DNA repair mechanisms employed by stem cells, we used hematopoietic stem cells (HSCs) isolated from young adult...
[26]Fletcher SC, Grou CP, Legrand AJ, et al. Sp1 phosphorylation by ATM downregulates BER and promotes cell elimination in response to persistent DNA damage[J]. Nucleic Acids Res, 2018, 46(4): 1834-1846. DOI: 10.1093/nar/gkx1291...
DNA损伤修复:DNA损伤修复(repair of DNA damage)是指在多种酶的作用下,生物细胞内的DNA分子受到损伤以后恢复结构的现象。DNA损伤修复的研究有助于了解基因突变的机制,衰老和癌变的原因,还可应用于环境致癌因子的检测。 文献介绍: 了解了DNA损伤修复后引入我们今天要介绍的一篇综述,一篇发表2021年7月发表在《Transducti...
DNA作为遗传信息的储存者,处在中心法则的起始环节,其损伤和修复会直接影响细胞命运。所以我们今天推荐的科研热点是DNA损伤修复。 一、什么是DNA损伤修复 由于外源性和内源性的因素,DNA损伤在细胞中不断发生,细胞因此进化出DNA损伤修复(DDR, DNA damage response),其中涉及多条参与调节细胞周期、染色质重塑、代谢、免疫...
Marc-Olivier Turgeon, et al. DNA Damage, Repair, and Cancer Metabolism. Front Oncol. 2018 Feb 5;8:15. Adrián Campos, et al. Cell Cycle and DNA Repair Regulation in the Damage Response: Protein Phosphatases Take Over the Reins. Int J Mol Sci. 2020 Jan 10;21(2):446. ...
近日，该团队在The Plant Cell杂志上发表了题为“Arabidopsis LAMIN-like proteins CRWN1/2 interact with SUPPRESSOR OF NPR1-1 and RAD51D to protect against DNA damage”的研究论文，揭示了植物细胞核纤层类似蛋白CRWN1/2在DNA断裂点处通过液-液相分离与SNI1和RAD51D一起形成“DNA修复小体（DNA repair body...
DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function. Cell Rep. 11, 785–797 (2015). Article CAS Google Scholar Freund, A., Patil, C. K. & Campisi, J. p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory ...
DNA damage sensing by the ATM and ATR kinases. Cold Spring Harb Perspect Biol. 2013 Sep 1;5(9):a012716. Andrew N Blackford, et al. ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response. Mol Cell. 2017 Jun 15;66(6):801-817. Joonyoung Her, et al. How ...