PHOTOS: Belly of the Beast: Bigger and Bloodier PHOTOS: Dive Into Shark Week 2024 John Cena Hosts Shark Week 2024 Shark Week 2024 Partners What You Can't Miss on Discovery This Week Shark Week 2024 By:Discovery Meet The Expedition Members on Expedition From Hell: The Lost Tapes ...
Discovery of a new class of cell-penetrating peptides by novel phage display platform Jinsha Liu, John Heddleston, Douglas Raymond Perkins, Jack Jia Hua Chen, Ahmadreza Ghanbarpour, Bill William Smith, Rebecca Miles, Eitaro Aihara & Sepideh Afshar Scientific Reports volume 14, Ar...
piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells piwi represents the first class of genes known to be required for stem cell self-renewal in diverse organisms. In the Drosophila ovary, piwi is required in... DN Cox,A Chao,HF ...
Example calculation of SpS and AWSpS within unordered hypothetical rules. Empty CellX1X2X3X4CLASSNUMEROSITYACCURACY R1 2 # # 1 0 5 0.73 R2 # 0 # 2 1 1 0.51 R3 2 0 # 1 0 2 0.88 R4 # 0 1 # 1 1 0.62 SpS 7 4 1 8 AWSpS 5.41 2.89 0.62 5.92 The intuition behind using ...
Most of the human genome encodes RNAs that do not code for proteins. These non-coding RNAs (ncRNAs) may affect normal gene expression and disease progression, making them a new class of targets for drug discovery. Because their mechanism... MasayukMasu,D Cory - 《Nature Reviews Drug Discove...
The discovery of the first class of subtype-selective inhibitors of the human excitatory amino acid transporter subtype 1 (EAAT1) and its rat orthologue GLAST is reported. An opening structure-activity relationship of 25 analogues is presented that addresses the influence of substitutions at the 4-...
In our continued effort to discover and develop best-in-class Bruton’s tyrosine kinase (Btk) inhibitors for the treatment of B-cell lymphomas, rheumatoid arthritis, and systemic lupus erythematosus, we devised a series of novel tricyclic compounds that improved upon the druglike properties of our...
With the aim of ensuring interworking between wireless and mobile networks, the 3GPP project has defined in release 6 [100] the techniques for interworking between 3GPP cell systems with WLAN wireless networks. Then, in release 8, the 3GPP project also introduced an access network discovery and ...
Expression of CD40L by T helper cells is a key ingredient for a functional T cell-dependent germinal centre response through stimulation of CD40 on B cells. Class switch recombination The rearrangement of constant regions at the immunoglobulin heavy chain locus. This results in the splicing out of...
The discovery builds on earlier findings showed that a class of genes called splicing (胶接) factors is progressively switched off as we age. The research team found that splicing factors can be switched back on with chemicals, making aging cells not only look 1 younger, but start to divide ...