Accordingly, a simple phenotypic screen for inhibition of bacterial growth was conducted to identify compounds, which were preselected for their promising physical chemical properties, for whole-cell antibacterial activity; the mode of action of hit compounds was subsequently determined using a 'reverse ...
This tagging process is kept in balance by a class of proteases which remove ubiquitin from proteins. These are the deubiquitinating enzymes (DUBs). DUB-mediated removal of ubiquitin saves tagged proteins from being degraded, but DUBs are also involved in more subtle editing of the polyubiquitin ...
As a structural class, IDPs are more tightly regulated than folded proteins from yeast to humans2 and, upon overexpression, are more prone to alter cell phenotype than their folded counterparts3. Thus, maintaining normal disordered protein homeostasis is critical for cellular behavior. The phenotypes...
The activity of all synthesized compounds against hSGLT2 and hSGLT1 was assessed using a cell-based SGLT1 and SGLT2 methyl-α-d-glucopyranoside (AMG) assay. Chinese hamster ovary cells expressing human SGLT1 or SGLT2 were used, and dapagliflozin (1) was used as a positive control.21 In ...
Structure-based discovery of the first allosteric inhibitors of cyclin-dependent kinase 2. Cell Cycle 2014, 13, 2296-2305. [CrossRef] [PubMed]Rastelli, G., Anighoro, A., Chripkova, M., Carrassa, L., & Broggini, M. (2014). Structure-based discovery of the first allosteric inhibitors ...
In addition, once a drug is on the market, patient stratification could accelerate drug expansion into new indications through faster, smaller, more definitive Phase IV trials, or to establish medical superiority of a late-to-market drug relative to entrenched competitors in an important class of ...
| tokyo | london | mannheim | moscow | hamburg | paris Shifting the Growing Costs of E-Discovery Since the arrival of e-discovery in the mid-1990s, Goes: Understanding Litigant Expenditures the cost of collecting, copying, reviewing, sorting, for Producing Electronic Discovery, 28 (2012). ...
Our mission is to discover the best-in-class therapeutics through the novel platforms. ATGC also strives to serve the biomedical community with products and technologies using our unique platforms. Monoclonal antibody development Stable expression cell line generation ...
et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286, 531–537 (1999). Article CAS PubMed Google Scholar Ash, A. et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403, ...
Plant Cell Rep. 26, 531–538 (2007). CAS PubMed Google Scholar Bradshaw, R. E. et al. Fragmentation of an aflatoxin-like gene cluster in a forest pathogen. New Phytol. 198, 525–535 (2013). This study reports the fragmentation of a gene cluster dedicated to the production of a ...