近日,我校基础医学院肿瘤表观遗传创新团队在中科院二区期刊《Cell Death Discovery》(IF=7.0)发表题为“FBXO22 promotes glioblastoma malignant progression by mediating VHL ubiquitination and degradation”的研究论文,研究结果表明,抑制FBXO2...
in-depth analysis of the proteome is needed. We employed immobilized pH gradient (IPG) strips that cover the full peptide pI range to enable the exploration of the entire tryptic peptidome (Fig.1a). As a model system, we used the A431 cell line (TMT10-plex labeled peptides...
Triple-negative breast cancer (TNBC) is a molecular subtype with an unfavorable prognosis, and metastasis is the main reason for the failure of clinical treatment. However, the expression profile and regulatory function of circRNAs in TNBC progression ar
2019年6月发表于《Cancer Discovery》的一篇题为“Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts”的文章,采用单细胞RNA测序(scRNA-Seq)将CAFs分为三个不同的亚群(myCAFs、iCAFs、apCAFs),并确定每个亚群的独特的基因信号分子及特定功能...
, useful, and fathomable patterns from large or complicated datasets. This process had been adopted by Horev-Azaria et al. to establish a predictive model for elucidating cytotoxic behavior of cobalt nanoparticles (CoNPs) using small-scale cell viability datasets [16]. They took advantage of a...
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(CTEP), the Cell Therapy Section (CTS) of the Clinical Center, and the CHI, NIH. The participation of Japanese and US scientists provided the opportunity to identify shared or discordant themes across the distinct immunogenetic background and the diverse disease prevalence of the two Nations and...
The high diversity and abundance is a feature of terrestrial molluscs wherein as many as 60–70 species may coexist in a single habitat. Molluscs belonging to class Gastropoda form the largest group with > 62,000 described living species. Gastropod molluscs have succeeded to occupy almost all ...
This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation. This addresses the challenge of finding organisms, genes, or pathways that consistently explain the differences between two or more...
function in acceptor cell, the process of packaging rnas into exosomes is still largely unknown. ohshimaa et al. found that let-7, a mirna family with relatively high abundance in six types of cancer cell, is only detectable in extracellular exosomes of gastric cancer cell (az-p7a) but ...