JERUSALEM, July 27 (Xinhua) -- Israeli researchers have discovered a new function of a protein in the cell, which can improve cancer treatment and wound healing, according to a study published Friday by Israel Institute of Technology "Technion." The study found that "caspase-3" protein not o...
临港实验室/中国科学院上海营养与健康研究所魏武课题组在《细胞发现(Cell Discovery)》上发表了题为“Deep learning models incorporating endogenous factors beyond DNA sequences improve the prediction accuracy of base editing outcomes”的...
The Gold Rush Mine Bosses Face Off Against the Next Generation of Miners A Shocking Change is Coming to Gold Rush Everybody is Kung-Fu Fighting on Kiddie Kai Shark Week: The Podcast – Forrest Galante on Walking Epaulette Sharks and Great Whites which can Change Color ...
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discovery of a number of rare cell sub-populations. Existing algorithms to find rare cells scale unbearably slowly or terminate, as the sample size grows to the order of tens of thousands. We propose Finder of Rare Entities (FiRE), an algorithm that, in a matter of seconds, assigns a ...
近日,我校王拥军教授带领团队基于中医阴阳理论指导,利用大型队列数据,结合表型组学策略,率先鉴定出了骨质疏松症(Osteoporosis,OP)临床分子分型,研究成果发表于国际权威杂志Cell Discovery。 OP是最多发、最严重的代谢性骨病。2023年,王拥军教授团...
Non-small cell lung cancer (NSCLC) patients with activating EGFR mutations initially respond to first-generation EGFR inhibitors; however, the efficacy of these drugs is limited by acquired resistance driven by the EGFR T790M mutation. The discovery of third-generation EGFR inhibitors overcoming EGFR ...
When a human cell detects a viral DNA, it generates cGAMP that leads to the activation of the interferon molecule, which in turn "calls" the immune system to help the infected cell. The first ancient organisms that had cell nucleus were already equipped with this anti-viral mechanism. ...
2022年11月16日,南方科技大学鄢仁鸿团队和田瑞琳团队合作在《Cell Discovery》期刊(IF:38.079)发表题为“Structures of ACE2–SIT1 recognized by Omicron variants of SARS-CoV-2 ”的文章。 新型冠状病毒Omicron变体的持续传播引发了新一波的COVID-19大流行,对全世界的公共卫生和经济发展造成严重威胁。自2022年2月...
Here, we develop paired guide RNAs for paralog genetic interaction mapping (pgPEN), a pooled CRISPR-Cas9 single- and double-knockout approach targeting more than 2,000 human paralogs. We apply pgPEN to two cell types and discover that 12% of human paralogs exhibit synthetic lethality in at...