The skeletal stem cell that gives rise to endosteal osteoblasts has been extensively studied; however, the identity of periosteal stem cells remains unclear. Here we identify a periosteal stem cell (PSC) that is present in the long bones and calvarium of mice, displays clonal multipotency and ...
Discovery of a periosteal stem cell mediating intramembranous bone formation Nature, 562 (2018), pp. 133-139, 10.1038/s41586-018-0554-8 View in ScopusGoogle Scholar Deledda et al., 2022 A. Deledda, E. Giordano, F. Velluzzi, G. Flore, S. Franceschelli, L. Speranza, P. Ripari Mitochond...
The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo differentiation into osteoblasts. This differentiation process plays a crucial role in bone formation and homeostasis and is regulated by two intricate processes: cell signal transduction and transcriptional gene expression. Vario...
Adult bone comprises three main cell types: osteoblasts, osteocytes (both of which are derived from mesenchymal stem cells (MSCs)), and osteoclasts (which are derived from hematopoietic stem cells (HSCs)). Regarding bone homeostasis, osteoblasts function to form bone tissue, osteoclasts resorb and ...