Adult bone comprises three main cell types: osteoblasts, osteocytes (both of which are derived from mesenchymal stem cells (MSCs)), and osteoclasts (which are derived from hematopoietic stem cells (HSCs)). Regarding bone homeostasis, osteoblasts function to form bone tissue, osteoclasts resorb and ...
Cell fate control and manipulation is a fundamental process in biology and enables the generation of desired cell types for regenerative medicine. Using chemical approach for reprogramming has become an advance in cell fate manipulation1,2. Somatic cells can be reprogrammed into pluripotent stem cells ...
The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo differentiation into osteoblasts. This differentiation process plays a crucial role in bone formation and homeostasis and is regulated by two intricate processes: cell signal transduction and transcriptional gene expression. Vario...
Adult bone comprises three main cell types: osteoblasts, osteocytes (both of which are derived from mesenchymal stem cells (MSCs)), and osteoclasts (which are derived from hematopoietic stem cells (HSCs)). Regarding bone homeostasis, osteoblasts function to form bone tissue, osteoclasts resorb and ...