Therefore, current attention is focused on the production of functional liver cells from human embryonic stem cells. The expectation is that in the future human pluripotent stem cells will prove to be a good source for the generation of human functional liver cells for drug toxicity testing.With contributions fromStefan Braa...
By contrast, the stem cells model suggests that cancer heterogeneity is due to the hierarchy that originates from a small population of cancer stem cells (CSCs) which are biologically distinct from the bulk tumor and possesses self-renewal, tumorigenic and multilineage potential. Although these two...
5 Peters, J. The role of genomic imprinting in biology and disease: an expanding view.Nat Rev Genet15, 517-530, doi:10.1038/nrg3766 (2014). 6 Zhong, C.et al.Parthenogenetic haploid embryonic stem cells efficiently sup...
Naturally occurring stem cells isolated from humans have been used therapeutically for decades. This has primarily involved the transplantation of primary cells such as haematopoietic and mesenchymal stem cells and, more recently, derivatives of pluripot
6. Morton J, Hutchins C, Durrant S:Granulocyte–colony-stimulating factor (G-CSF)–primed allogeneic bone marrow: significantly less graft-versus-host disease and comparable engraftment to G-CSF–mobilized peripheral blood ...
2024年3月29日,浙江大学基础医学院/良渚实验室钱鹏旭研究员团队在Cell Discovery上发表了题为“Microplastics Dampen the Self-renewal of Hematopoietic Stem Cells by Disrupting the Gut Microbiota-Hypoxanthine-Wnt Axis”的研究论文,该研究通过构建小鼠微塑料模型,证明长期摄入微塑料可对HSCs的数目与功能造成严重的损害...
今天,我们特别介绍一项张教授于2022年10月11日发表在《Cell Discovery》的近期研究——Generation of high-performance human cardiomyocytes and engineered heart tissues from extended pluripotent stem cells,该研究利用人扩展多能干细胞(EPSC)诱导出心肌细胞,并测试了这种新型来源的心肌细胞的性能,为心脏相关研究提供了...
Cellular senescence is a stress response involved in ageing and diverse disease processes including cancer, type-2 diabetes, osteoarthritis and viral infection. Despite growing interest in targeted elimination of senescent cells, only few senolytics are known due to the lack of well-characterised molecul...
Our lab has discovered that pluripotent and totipotent stem cells are present within the skeletal muscle and dermis of adult mammals, including humans. These cells are very plastic, more than the lineage specific stem cells accepted to be present at this time. These adult stem cells are very ...
5 Li, L. et al. Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal Niche Interactions. Cell Stem Cell 20, 858-+, doi:10.1016/j.stem.2017.03.007 (2017). 6 Tang, W. W. C. et al....