The mice were irradiated with enough X-rays to kill them within 30 days if they did not receive a transplant of bone marrow cells. The mice were also injected with a varying number of cells in order for the researchers to determine how many cells it would take to keep the animals alive....
In all cases though, drugs interact at the molecular level with either the cell type or tissue in the body affected by and/or causing the disease; in the case of an infectious disease they may also kill the responsible microorganism or virus, eliminating it from the body to exert a ...
(2012). On murine mammary epithelial stem cells: discovery, function, and current status . Cold Spring Harb. Perspect. Biol . 4 , a013268. 10.1101/... Rosen,M J. - 《Cold Spring Harb Perspect Biol》 被引量: 88发表: 2012年 Association of reactive oxygen species levels and radioresistance...
Our lab has discovered that pluripotent and totipotent stem cells are present within the skeletal muscle and dermis of adult mammals, including humans. These cells are very plastic, more than the lineage specific stem cells accepted to be present at this time. These adult stem cells are very ...
Therefore, it may be more appropriate to describe the majority of NCCs as progeni- tor cells rather than true stem cells [4]. Progenitor cells like stem cells have the capacity to self-renew and dif- ferentiate, but in contrast to stem cells both capacities are more limited. Despite these...
Immune cells (T cells, green) can be see entering the cornea of the eye, towards the Herpes Simplex virus infected cells (light blue). The eye is rich in nerves (purple). Credit: Doherty Institute The cornea—the transparent protective outer layer of the eye critical to helping us see—...
2024年3月29日,浙江大学基础医学院/良渚实验室钱鹏旭研究员团队在Cell Discovery上发表了题为“Microplastics Dampen the Self-renewal of Hematopoietic Stem Cells by Disrupting the Gut Microbiota-Hypoxanthine-Wnt Axis”的研究论文,该研究通过构建小鼠微塑料模型,证明长期摄入微塑料可对HSCs的数目与功能造成严重的损害...
5 Peters, J. The role of genomic imprinting in biology and disease: an expanding view.Nat Rev Genet15, 517-530, doi:10.1038/nrg3766 (2014). 6 Zhong, C.et al.Parthenogenetic haploid embryonic stem cells efficiently sup...
Cell Discovery publishes results of high significance and broad interest in all areas of molecular and cell biology, including (but not limited to) the following topics: cell growth and differentiation, signal transduction, apoptosis, stem cells, ...
今天,我们特别介绍一项张教授于2022年10月11日发表在《Cell Discovery》的近期研究——Generation of high-performance human cardiomyocytes and engineered heart tissues from extended pluripotent stem cells,该研究利用人扩展多能干细胞(EPSC)诱导出心肌细胞,并测试了这种新型来源的心肌细胞的性能,为心脏相关研究提供了...