The mice were irradiated with enough X-rays to kill them within 30 days if they did not receive a transplant of bone marrow cells. The mice were also injected with a varying number of cells in order for the researchers to determine how many cells it would take to keep the animals alive....
In all cases though, drugs interact at the molecular level with either the cell type or tissue in the body affected by and/or causing the disease; in the case of an infectious disease they may also kill the responsible microorganism or virus, eliminating it from the body to exert a ...
Tumors are known to be heterogeneous containing a dynamic mixture of phenotypically and functionally different tumor cells. The two concepts attempting to explain the origin of intratumor heterogeneity are the cancer stem cell hypothesis and the clonal evolution model. The stochastic model argues that tu...
Stem-cell discovery platforms yield first clinical candidates: Induced pluripotent stem cell-derived 'disease-in-a-dish' models have propelled neurological... A Mullard 被引量: 0发表: 2015年 Cognitive neuroscience of emotional memory. Nature Reviews Drug Discovery Nature Reviews Molecular Cell Biology...
In the womb, the human embryo early on becomes three "germ" layers of stem cells – the endoderm, mesoderm and ectoderm. The long-held consensus was that the endoderm goes on to form the liver and other gut organs; the mesoderm the heart, muscles and blood cells; and the ectoderm the ...
Therefore, it may be more appropriate to describe the majority of NCCs as progeni- tor cells rather than true stem cells [4]. Progenitor cells like stem cells have the capacity to self-renew and dif- ferentiate, but in contrast to stem cells both capacities are more limited. Despite these...
Cell Discovery is an open access journal, publishing high quality original articles and reviews covering all aspects of cell biology and molecular biology.
2024年3月29日,浙江大学基础医学院/良渚实验室钱鹏旭研究员团队在Cell Discovery上发表了题为“Microplastics Dampen the Self-renewal of Hematopoietic Stem Cells by Disrupting the Gut Microbiota-Hypoxanthine-Wnt Axis”的研究论文,该研究通过构建小鼠微塑料模型,证明长期摄入微塑料可对HSCs的数目与功能造成严重的损害...
LifeMap Discovery provides information on two main types of cultured cells: Source cells – can be used to initiate differentiation protocols or cell therapies. This category includes embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), embryonic progenitor cells, fetal and adult ...
今天,我们特别介绍一项张教授于2022年10月11日发表在《Cell Discovery》的近期研究——Generation of high-performance human cardiomyocytes and engineered heart tissues from extended pluripotent stem cells,该研究利用人扩展多能干细胞(EPSC)诱导出心肌细胞,并测试了这种新型来源的心肌细胞的性能,为心脏相关研究提供了...