In order for cancer to occur, the immune system must have failed. Dendritic cells are found in all tissues of the body, and many of them began as macrophages. The first dendritic cell discovered is found throughout the skin and is called a Langerhan's cell. Dendritic cells are a ...
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Chang DH, Dhodapkar MV. Dendritic cells and immu- notherapy for cancer. Int J Hematol 2003;77(5):439-43 [Review].Chang DH, Dhodapkar MV (2003) Dendritic cells and immunotherapy for cancer. Int J Hematol 77:439–443D.H. Chang, M.V. Dhodapkar, Dendritic cells and immunotherapy ...
P. et al. NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control. Cell 172, 1022–1028.e14 (2018). Article PubMed PubMed Central CAS Google Scholar Barry, K. C. et al. A natural killer–dendritic cell axis defines checkpoint therapy–...
In one approach, autologous antigen-specific T cells are expanded ex vivo and then re-infused into patients. Another approach is through vaccination; that is, the provision of an antigen together with an adjuvant to elicit therapeutic T cells in vivo. Cancer vaccines aim to induce tumour-...
Dendritic cells (DCs), the most prevalent antigen-presenting cell in vivo, had been widely characterized in the last three decades. DCs are present in almo
- 《Molecular Therapy》 被引量: 89发表: 2009年 Advances in dendritic cell-based vaccine of cancer. Dendritic cells (DCs) are potent antigen presenting cells that exist in virtually every tissue, and from which they capture antigens and migrate to seconda... Xueshu,Zhang,R John,... - 《...
Objective:Using apoptotic tumor cells-loaded dendritic cells (DCs) to activate the antigen-specific cytotoxic T lymphocytes (CTL) and observe their effects... JA Huang,XJ Yang,HU Yu-Min,... - 《Tumor》 被引量: 4发表: 2007年 The use of dendritic cells in cancer therapy Although the immune...
At the interface between the innate and adaptive immune system, dendritic cells (DCs) play key roles in tumour immunity and hold a hitherto unrealized potential for cancer immunotherapy. Here we review the role of distinct DC subsets in the tumour microenvironment, with special emphasis on conventio...
cells that can control tumour relapse. Owing to their capacity to regulate T-cell immunity, dendritic cells are increasingly used as adjuvants for vaccination, and the immunogenicity of antigens delivered by dendritic cells has now been shown in patients with cancer. A better understanding of how...