Cancer immunologyCancer immunotherapyDendritic cell subsetDendritic cell targetingDendritic cell vaccineDendritic cellsImmunotherapyTumor immunologyVaccinesCancer immunotherapy harnesses the ability of the immune system to recognize and eliminate cancer. The potent ability of dendritic cells (DCs) to initiate and ...
Myeloid cells can favour or hinder each step of the metastatic cascade. Myeloid cells have a central, yet still largely unexplored, role in virtually all therapeutic modalities, including surgery, chemotherapy, radiotherapy, immunotherapy and targeted therapy. Modulating myeloid cell functions in therapy...
Immune checkpoint blocking (ICB) is a promising new tool of cancer treatment. Yet, the underlying therapeutic mechanisms are not fully understood. Here we investigated the role of dendritic cells (DCs) for the therapeutic effect of ICB in a 位-MYC-transgenic mouse model of endogenously arising ...
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The function of EVs in development EV-mediated control of aging and metabolism The impact of EVs on tissue repair, response to stress, and immunity The role of EVs in inflammation, obesity, and cancer initiation The functional contribution of EVs to cancer progression EVs in mediating cancer meta...
Dendritic cells (DCs) play a key role in initiating immune responses and maintaining immune tolerance. In addition to playing a role in thymic selection, DCs play an active role in tolerance under steady state conditions through several mechanisms which are dependent on IL-10, TGF-β, retinoic ...
MDSCs are immature myeloid immune cells, which accumulate in models of liver cancer to reduce effector immune cell activity, contribute to immune escape and treatment resistance. The accumulation of MDSCs suppresses the role of CTL and the killing effects of NK cells, induces the accumulation of ...
J Exp Clin Cancer Res (2022) 41:127 https://doi.org/10.1186/s13046-022-02340-2 REVIEW Open Access The role of tumor‑infiltrating lymphocytes in cholangiocarcinoma Dong Liu1, Lara Rosaline Heij1,2,3, Zoltan Czigany1, Edgar Dahl2, Sven Arke Lang1, Tom Florian ...
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release
Hyperactivation of RAF proteins, particularly BRAF and CRAF, drives tumour progression and drug resistance in many types of cancer. Although BRAF is the most studied RAF protein, partially owing to its high mutation incidence in melanoma, the role of CRAF in tumourigenesis and drug resistance is ...