Dendritic cells in cancer immunother- apy: vaccines and combination immunotherapies. Expert Rev Vaccines (2013) 12:285-95. doi:10.1586/erv.13.22Kalinski P, Muthuswamy R, Urban J.. Dendritic cells in cancer immunotherapy: vaccines and combination immunotherapies . Expert Rev Vaccines (2013) 12 :...
Dendritic cells (DCs) are a diverse group of specialized antigen-presenting cells with key roles in the initiation and regulation of innate and adaptive immune responses. As such, there is currently much interest in modulating DC function to improve cancer immunotherapy. Many strategies have been de...
In contrast, there are relatively few studies on human DC subsets and their function. Mouse and human DC subsets are not homologous, making DCs and Their Use in Immunotherapy To generate an autologous DC vaccine in vitro, peripheral blood mononuclear cells (PBMC) are isolated from the patient ...
Dendritic Cellsresearch area Cytokines and Growth Factors CD40 Ligand/TNFSF5IFN-gammaIL-10VEGF GDF-15IL-1 beta/IL-1F2IL-12Wnt-5a GM-CSFIL-3MFG-E8 IFN-alphaIL-6TNF-alpha Flow Cytometry Antibodies 4-1BB Ligand/TNFSF9CD11cGM-CSF R alphaPD-L2/B7-DC ...
" Dendritic Cells and Immunotherapy for Cancer, " Int. J. Hematol. 77(5):439-443.Chang DH, Dhodapkar MV. (2003). Dendritic cells and immunotherapy for cancer. Int J Hematol, 77 (5), 439-43.ZHAN De-wen, LIU Xiang-xin, ZHANG Zhao-shanInstitute of Biotechnology, Academy of Military...
Cancer immunotherapy attempts to harness the power and specificity of the immune system to treat tumours. The molecular identification of human cancer-specific antigens has allowed the development of antigen-specific immunotherapy. In one approach, autologous antigen-specific T cells are expanded ex vivo...
The technology of gene transfer into dendritic cells has been established in recent years. Strategies for the application of dendritic cells in cancer immunotherapy include the use of non-specific protein fractions, specific peptides, tumor antigen RNA and tumor antigen gene transduction of dendritic ...
These studies show that antigen-loaded dendritic cell vaccinations are safe and promising in the treatment of cancer. This review discusses the use of dendritic cells in immunotherapy and some of the clinical trials that have been conducted.
The clinical application of cancer immunotherapy based on naturally circulating dendritic cells Introduction Acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) are common hematopoietic diseases characterized by uncontrolled clonal malignant cell proliferation with leukemic blasts replacing the cells ...
Eggermont and Carl G. Figdor provide an overview of immunotherapeutics for cancer treatment that harness dendritic cells, their challenges in clinical use, and approaches employed to enhance their recruitment and activation to promote effective anti-tumour immunity.关键词:...