Breast cancerCalcium carbonateCancer cell membraneCe6Dendritic cell vaccineDoxCancer vaccine is widely considered as a powerful tool in immunotherapy. In particular, the effective antigen processing and presentation natures of dendritic cell (DC) have made it a promising target for the development of ...
et al. Agonist anti-GITR antibody enhances vaccine-induced CD8+ T-cell responses and tumor immunity. Cancer Res. 66, 4904–4912 (2006). Article CAS PubMed PubMed Central Google Scholar Buchan, S. L. et al. PD-1 blockade and CD27 stimulation activate distinct transcriptional programs that...
cell immunity, dendritic cells are increasingly used as adjuvants for vaccination, and the immunogenicity of antigens delivered by dendritic cells has now been shown in patients with cancer. A better understanding of how dendritic cells regulate immune responses will allow us to better exploit these...
Cancer vaccine: dendritic cells + tumour cellsInpharma Weekly -doi:10.2165/00128413-199710900-00015NoneSpringer International PublishingInpharma Weekly
Furthermore, a preclinical study on the effect of a DC vaccine loaded with tumor cell lysate (TCL-DCV) on the percentage of CD166+cancer stem cells (CSCs) in the lungs of mice exposed to benzo(a)pyrene (BP) revealed that TCL-DCV reversed the tumorigenic effect of BP in the lungs. Co...
Dendritic cell (DC) vaccines represent a personalized approach in cancer immunotherapy, utilizing the patient's own dendritic cells to stimulate an immune response against cancer cells. The paper overviews the mechanisms of DC vaccines and their clinical applications in acute myeloid leukemia (AML), ...
Work with dendritic cell vaccine in the treatment of colorectal cancer is still largely in the preclinical phase. In murine models, dendritic cell vaccines have been shown to induce antitumor responses.67–69 The experimental evidence in humans to date has mainly been limited to studies of ...
A hepatic stem cell vaccine is superior to an embryonic stem cell vaccine in the prophylaxis and treatment of murine hepatocarcinoma. Stem cells and cancer cells express a common subset of antigens called oncofetal antigens. Theoretically, vaccination with stem cells is effective at boost... Qi...
Early clinical trials, in which over 1000 cancer patients received dendritic cell (DC) vaccines, tested different vaccine preparations, but they did not always induce sufficient acquired immunity or meet the expected level of tumor regressions. Current studies aim to improve the DC vaccine approach ...
Accordingly, pDCs isolated from the human blood induced IFN-driven T cell responses in melanoma patients44. Although concerns for pDC-mediated immunosuppression may exist39,40,41, the aforementioned pre-clinical and clinical results suggest that pDCs may hold promise as effective anti-cancer vaccine ...