Dendritic cell vaccineDoxCancer vaccine is widely considered as a powerful tool in immunotherapy. In particular, the effective antigen processing and presentation natures of dendritic cell (DC) have made it a promising target for the development of therapeutic vaccine for cancer treatment. Here in ...
Therapeutic HPV cancer vaccine targeted to CD40 elicits effective CD8+ T-cell immunity. Cancer Immunol. Res. 4, 823–834 (2016). Article CAS PubMed Google Scholar Hangalapura, B. N. et al. CD40-targeted adenoviral cancer vaccines: the long and winding road to the clinic. J. Gene Med....
DCs—particularly cDC1s—comprise a versatile cell type capable of engaging multiple facets of the immune system, providing a highly modular vaccine platform potentially applicable to a broad range of cancers. However, DC vaccines have yet to be fully realized as an immunotherapy. Although genetically...
Dendritic cell (DC) vaccines represent a personalized approach in cancer immunotherapy, utilizing the patient's own dendritic cells to stimulate an immune response against cancer cells. The paper overviews the mechanisms of DC vaccines and their clinical applications in acute myeloid leukemia (AML), ...
targeting therapies, have been explored. After a decade of trials and tribulations, much progress has been made and much promise has emerged in the field. In this review we summarize the recent advances in DC vaccine immunotherapy for AML/MDS as well as other nonleukemia malignancies....
However, in view of the expected emergence of antigen-loss variants as well as natural immunovariation, effective vaccine formulations must contain mixtures of commonly, if not universally, expressed tumor antigens. When, or even if, such common tumor antigens will be identified cannot be, ...
Another pilot clinical trial involving 25 platinum-treated, immunotherapy-naïve, recurrent epithelial ovarian cancer patients evaluated the safety and effectiveness of a personalized DC-based vaccine generated by differentiation of autologous DCs pulsed with oxidized autologous whole-tumor cell lysate (OCDC...
.It is the unique APC that can activate the initial immunological response,and play a important role in active immunity against tumor.The research of DCs is the focus of tumor immunotherapy.This article reviewed the biological character,anti-tumor mechanism and the preparation of tumor-vaccine on ...
Advances in Dendritic Cell-Based Vaccines for HIV.HIV-1ImmunotherapyInnate immunityRNA interference (RNAi)Targeted deliveryHIV remains one of the most important deadly infections today, due to the lack of a preventive vaccine and limited access to medical care in developing countries. In developed ...
Mouse studies have shown that the immune system can reject tumours, and the identification of tumour antigens that can be recognized by human T cells has facilitated the development of immunotherapy protocols. Vaccines against cancer aim to induce tumour-specific effector T cells that can reduce the...