M., et al. Characterization of the human nu- cleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differen- tiation. Arthritis Rheum. 62(12):3695-3705, 2010.Minogue BM, Richardson SM, Zeef LAH, Freemont AJ, Hoyland JA (2010) ...
Nestin is a type VI intermediate filament (IF) protein originally identified as a marker for neural stem cells in early development14. It was later found to be expressed in many other stem/progenitor cell populations, promoting its application as a marker to isolate various adult stem cells, in...
Nestin-GFP reporter expression defines the quiescent state of skeletal muscle satellite cells Repair of adult skeletal muscle depends on satellite cells, quiescent myogenic stem cells located beneath the myofiber basal lamina. Satellite cell numbers... K Day,G Shefer,JB Richardson,... - 《Development...
In the immune system of vertebrates, the thymus controls the development of αβT-cells that play multiple and essential roles in immune responses1. In the adult thymus, intrathymic microenvironments are heterogeneous, with the cortex and medulla being formed from a range of non-hemopoietic stroma...
Comparative Evaluation of Human Mesenchymal Stem Cells of Fetal (Wharton's Jelly) and Adult (Adipose Tissue) Origin during Prolonged In Vitro Expansion: Co... Mesenchymal stem cells (MSCs) are somatic cells with a dual capacity for self-renewal and differentiation, and diverse therapeutic applicabil...
However, this putative mesenchymal stem/progenitor cell is yet to be identified and isolated. We are reporting the identification, isolation, and detailed characterization of the most primitive mesenchymal progenitor cells in the adult murine bone marrow, based on the expression of stage-specific ...
Hematopoiesis in the vertebrate is characterized by the induction of ventral mesoderm to form hematopoietic stem cells and the eventual differentiation of these progenitors to form the peripheral blood lineages. Several genes have been implicated in the differentiation and development of hematopoietic and ...
The ATX2-dependent translation of PER is most evident in ∼150 circadian pacemaker neurons present in adult fly brains (Figure 1A). Genetic disruptions in Atx2 or tyf dampen the high-amplitude PER cycling with 24 hr periodicity in these cells, leading to long, weak locomotor rhythms in ...
stem cellsUCP2Cellular replacement in the heart is restricted to postnatal stages with the adult heart largely postmitotic. Studies show that loss of regenerative properties in cardiac cells seems to coincide with alterations in metabolism during postnatal development and maturation. Nevertheless, whether...
Lung squamous cell carcinoma, normal adult pancreas and hippocampus were used as positive controls for TNC, LAMA2 and NELL2, respectively. Despite dif- ferent pretreatment protocols and antibody dilutions, no reliable and reproducible results could be obtained for the NELL2 antibody. Therefore, we ...