Interestingly, these results suggest that AD-MSCs may be a more appropriate cell type than BM-MSCs for use in engineering intervertebral disc tissue.Ben M. MinogueStephen M. RichardsonLeo A. H. Zeef, Anthony J. Freemont, Judith A. Hoyland...
Developmental and regenerative mechanisms are directed by stem cell populations. Skeletal muscle is a dynamic tissue that is capable of adapting to stress and severe injury due to a resident somatic stem cell population. In response to a severe injury that destroys upward of 90% of the tissue, ...
Male reproductive system ageing is closely associated with deficiency in testosterone production due to loss of functional Leydig cells, which are differentiated from stem Leydig cells (SLCs). However, the relationship between SLC differentiation and age
AsSSCs represent 0.02–0.03% of all germ cells in the adult testes8. At present, three models for SSC renewal have been proposed9,10. In the classic Asinglemodel, the daughters of a dividing Ascell either contribute to maintenance of the SSC pool or begin to differentiate. In the fragment...
We report here a novel role for uncoupling protein 2 (UCP2) in regulation of functional properties in cardiac tissue derived stem-like cells (CTSCs). CTSC were isolated from C57BL/6 mice aged 2 days (nCTSC), 2 month (CTSC), and 2 years old (aCTSC), subjected to bulk-RNA sequencing...
We established UAS-LSM12 transgenic flies that could overexpress LSM12 in combination with tissue-specific or inducible Gal4 drivers. When cryptochrome (cry)-Gal4 was used to overexpress LSM12 in circadian pacemaker neurons, no significant effect was seen in the free-running circadian behaviors of...
Comparative Evaluation of Human Mesenchymal Stem Cells of Fetal (Wharton's Jelly) and Adult (Adipose Tissue) Origin during Prolonged In Vitro Expansion: Co... Mesenchymal stem cells (MSCs) are somatic cells with a dual capacity for self-renewal and differentiation, and diverse therapeutic applicabil...
The adult bone marrow has generally been seen as an organ composed of 2 main and distinct lineages: the hematopoietic tissue and a group of mesenchymal-derived cells. It is believed that the bone marrow mesenchymal compartment contains stem/progenitors of skeletal tissue components such as bone, ...
TNC immunoreactivity was extracellular (Fig. 1c) and different expression patterns including predominantly perivascular areas, the central or the border-zone of the tumor tissue, as well as a mixture of these patterns was observed. LAMA2 expression was cytoplasmic (Fig. 1d). TNC and Araki et ...
Interestingly, these results suggest that AD-MSCs may be a more appropriate cell type than BM-MSCs for use in engineering intervertebral disc tissue.doi:10.1002/art.27710Ben M. MinogueUniversity of Manchester, Manchester, UKStephen M. Richardson...