Typically, adult stem cells are thought to have limited differentiation potential restricted to the cells found in the tissue where the stem cells reside. However, others have reported on a phenomenon referred to astransdifferentiation, whereby an adult stem cell can differentiate into cell types obse...
Current stem cell research & therapyKuci S, Kuci Z, Latifi-Pupovci H, Niethammer D, Hand- gretinger R, Schumm M, Bruchelt G, Bader P, Klingebiel T. Adult stem cells as an alternative source of multipotential (pluripotential) cells in regenerative medicine. Curr Stem Cell Res Ther. 2009...
There is considerable interest in the biology and therapeutic potential of adult stem cells from bone marrow stroma, variously referred to as mesenchymal stem cells or marrow stromal cells (MSCs). Human MSCs can expand rapidly in culture, but the rate of expansion and the yields of multipotential...
We have identified a novel source of adult stem cells from the external murine ears referred to here as an ear mesenchymal stem cells (EMSC). EMSC have been isolated from several standard and mutant strains of mice. They are self-renewing, clonogenic, and multipotent, since they give rise ...
Adult stem cell-derived (ASC) organoids can be derived from most epithelial tissues and are emerging as an important tool to bridge the gap between 2D cell lines and in vivo animal models. With their 3D-organization and cellular heterogeneity, organoids closely resemble the tissue of origin and...
Significant progress has been made to identify the cells at the foundation of tumorigenesis, the cancer cell of origin (CCO). The majority of data points towards resident adult stem cells (ASCs) or primitive progenitors as the CCO for those cancers studied, highlighting the importance of stem ...
Hailed as a potential alternative to embryonic stem cells, induced pluripotent stem cells (iPS cells) raise their own ethical dilemmas
Fig. 2: Hippocampal cells lacking KAT3 fail to express neuronal-specific genes. a Cumulative graph showing the log2 fold-change value of DEGs in dKAT3-ifKOs (mRNA-seq, 1 month after TMX, n = 3 per genotype). Upregulated genes are presented in red and downregulated genes in blue ...
Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of nutrients while acting as a barrier for hostile luminal cont
The demethylated cells were then transfected with a Flpe plasmid, causing the stop cassette to be excised (2frt → 1frt), the Dnmt1 allele to be reactivated, and genome methylation to be restored (Figure 1A; Figure S1; these cells are herein referred to as “IF-ES cells”) (Buchholz...