Adult somatic stem cells, also called progenitors, are essential for tissue regeneration and homeostasis. Stem cells have been identified in almost all tissues including those with little regenerative capacity. It is a central interest in the field of regenerative medicine to understand the signals ...
adult stem cells do not normally generate cell types foreign to their native tissue/organ. Adult stem cells reside in specificstem cell nichesand have been found in the bone marrow, the peripheral blood, postnatalumbilical cord, the skin, the cornea and thegastrointestinal tract, amongst others....
Besides hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs), endothelial progenitor cells (EPCs) and even solid-organ tissue resident stem cells (e.g. cardiac stem cells [CSC]) are known to contribute to solid-organ tissue repair. Stem cell delivery for cardiac tissue repair is by...
Maintaining Tissue Homeostasis: Dynamic Control of Somatic Stem Cell Activity Long-term maintenance of tissue homeostasis relies on the accurate regulation of somatic stem cell activity. Somatic stem cells have to respond to tissue d... Benoit,Biteau,and,... - 《Cell Stem Cell》 被引量: 233发...
The naked mole rat (NMR), Heterocephalus glaber, the longest-living rodent, provides a unique opportunity to explore how evolution has shaped adult stem cell (ASC) activity and tissue function with increasing lifespan. Using cumulative BrdU labelling and
Embryonic stem cells are the only type of stem cells that are pluripotent. Embryonic stem cells within the first few cell divisions after forming the zygote are called totipotent. This means that they can become any cell type in the body and any extraembryonic tissue as well. Embryonic Stem ...
Characterization of human adult stem-cell populations isolated from visceral and subcutaneous adipose tissue.Characterization of human adult stem-cell populations isolated from visceral and subcutaneous adipose tissue.doi:10.1096/fj.08-196946ASCsimmunophenotypingmesenchymalstromal...
Adult stem cells maintain tissue homeostasis by their ability to both self-renew and differentiate to distinct cell types. Multiple signaling pathways have been shown to play essential roles as extrinsic cues in maintaining adult stem cell identity and activity. Recent studies also show dynamic regulat...
However, the advantage of in situ hybridization is that it provides spatial information about relative expression levels in different cell populations within a heterogeneous tissue, which was the primary goal of our analysis. The results are presented in Table 1. Figure 2 Definition of CMZ regions ...
Finally, we detail the potential involvement of the SC niche in tissue degeneration, with a particular emphasis on aging and cancer.doi:10.1016/B978-0-12-416022-4.00012-3Amélie RezzaRachel SennettMichael RendlPubMedCurrent Topics in Developmental Biology...