IL-15 might exert direct effects on memory CD8+T cells or might act on other cell types, which subsequently regulate memory T-cell proliferation. IL-15 might also be presented by other cells to CD8+T cells through interaction with the IL-15 receptor β-chain. ...
Cellular metabolism regulates the differentiation and function of T-cell subsets Sicong Ma Yanan Ming Guoliang Cui Cellular & Molecular Immunology(2024) Prmt5 deficiency inhibits CD4+ T-cell Klf2/S1pr1 expression and ameliorates EAE disease
To our knowledge, this study provides the first direct immunophenotypic evidence of cytokine producing CD8 + T cells being directly related to long-term development of MRI features of demyelination and axonal loss. 展开 关键词: Cytokines Multiple sclerosis CD8 + T cells MRI EDSS ...
By using flow cytometry for the detection of cytokines, a more pronounced T helper (Th)2 cell-type response with the expansion of interleukin (IL)-4, , and expressing + cells in the microfilaremic compared with the amicrofilaremic group was noted. Expression of was equivalent in both ...
Diagnosis of metal allergy through cytokine release by T-cells in vitro An in vitro method for diagnosing a contact allergy in a subject comprises: (i) providing (a) a contact allergen; (b) T-cells from said subject; and (c) a surface to which is immobilized a first specific binding ...
[1].Hjelm Skog AL, Wadhwa M, Hassan M, Gharizadeh B, Bird C, Ragnhammar P, Thorpe R, Mellstedt H. Alteration of interleukin 2 (IL-2) pharmacokinetics and function by IL-2 antibodies induced after treatment of colorectal carcinoma patients with a combination of monoclonal antibody 17-1A,...
Characterization of chemical allergens as a function of divergent cytokine secretion profiles induced in mice. Allergic contact dermatitis (contact sensitivity) may be caused by a wide variety of chemicals. In addition, some chemical allergens may also induce respir... RJ Dearman,DA Basketter,I ...
The adhesion of lymphocytes to cytokine-treated high endothelium was studied using cultured high endothelial cells (HEC). Pretreatment of the HEC layer wit... MJ May,A Ager - 《European Journal of Immunology》 被引量: 146发表: 1992年 Function and dysfunction of CD4(+) T cells in the immune...
The cytokine interferon (IFN)-γ produced by tumor-reactive T cells is a key effector molecule with pleiotropic effects during anti-tumor immune responses. Although IFN-γ production is targeted at the immunologic synapse, its spatiotemporal activity wit
T cells. Signals from low-affinity pMHC and cytokines synergistically induce phosphorylation of the kinase Akt, metabolic changes and c-Myc transcription factor induction in CD8+T cells only in the presence of Themis. This function of Themis is mediated through Shp1 phosphatase, as peripheral ...