Interleukin-2 and the IL-2 receptor: new insights into structure and function. J Invest Dermatol. 1990 Jun;94(6 Suppl):27S-32S. doi: 10.1111/1523-1747.ep12875017. PMID: 1693645. [11].Schneider A, Gorr IH, Larraillet V, Frensing T, Popp O. Reduction of IL-2 fragmentation during ...
[5] P.T. Thevenot, R.A. Sierra, P.L. Raber, A.A. Al-Khami, J. Trillo-Tinoco, P. Zarreii, A.C. Ochoa, Y. Cui, L. Del Valle, P.C. Rodriguez, The stress-response sensor chop regulates the function...
The cytokine interferon (IFN)-γ produced by tumor-reactive T cells is a key effector molecule with pleiotropic effects during anti-tumor immune responses. Although IFN-γ production is targeted at the immunologic synapse, its spatiotemporal activity wit
NKTR-358: a novel regulatory T-cell stimulator that selectively stimulates expansion and suppressive function of regulatory T cells for the treatment of autoimmune and inflammatory diseases. J. Transl Autoimmun. 4, 100103 (2021). Article Google Scholar Bristol Myers Squibb. Nektar and Bristol Myers...
FunctionPlaysaroleintheinducibleexpressionofcytokinegenesinT-cells,especiallyintheinductionoftheIL-2,IL-3,IL- 4,TNF-alphaorGM-CSF. TissuespecificityExpressedinthymus,spleen,heart,testis,brain,placenta,muscleandpancreas. SequencesimilaritiesContains1RHD(Rel-like)domain. DomainRelSimilarityDomain(RSD)allowsDNA-...
T cells use two directionally distinct pathways for cytokine secretion. Nat. Immunol. 7: 247-255.Huse M, Lillemeier BF, Kuhns MS, Chen DS, Davis MM. T cells use two directionally distinct pathways for cytokine secretion. Nat Immunol. (2006) 7:247-55. doi: 10.1038/ni1304...
Abraham E, Chang YH (1992) Haemorrhage-induced alteration in function and cytokine production of T cells and T cell subpopulations. Clin Exp Immunol 90:497–502 PubMedCASGoogle Scholar Hershman M J, Cheadle WG, Wellhausen SR, Davidon P, Polk HC ( 1990) Monocyte HLA-DR antigen expression ch...
Little is known about the type 1/type 2 T cell dichotomy in old age. Peripheral blood mononuclear cells (PBMC) and T cell lines from old and young healthy individuals were therefore analyzed for their production of interferon gamma (IFN-γ) and interleukin 4 (IL-4). Tetanus toxoid (TT),...
Human decidual stromal cells suppress cytokine secretion by allogenic CD4+ T cells via PD-1 ligand interactions. BACKGROUND: Although previous reports suggest an antigen-presenting function for decidual stromal cells (DSCs), the relevance of cell-to-cell communication... Nagamatsu,Takeshi,Schust,......
Studies in mice [27] and humans [23] have shown that c-Maf is a key inducer of IL-21 production and is therefore a key molecule conferring Tfh function. However, simultaneous expression of Bcl-6 is necessary to repress transcriptional programming that instructs other T helper cell lineage ...