Cytokines regulation of T cell function: potential for therapeutic intervention. Immunol Today 1993;14:270–274.Powrie, F., and R.S. Coffman (1993): Cytokine regulation of T-cell function: potential for therape
regulated in Tregcells co-cultured with Teffcells, thereby boosting Ebi3 and IL-12α productionin trans. Treg-cell restriction of this cytokine occurs becauseEbi3is a downstream target of Foxp3, a transcription factor that is required for Treg-cell development and function.Ebi3–/–andIl12a–/...
The disruptor of telomeric silencing 1-like (DOT1L) promotes peritoneal fibrosis through the upregulation and activation of protein tyrosine kinases Min Tao Yingfeng Shi Na Liu Molecular Biomedicine(2024) Cellular metabolism regulates the differentiation and function of T-cell subsets ...
(for regulation of IgG class switching and production of pathogenic autoantibody[14]), and natural killer (NK) cells (as a determinant of maturation andhomeostasis[15])). And finally, T-bet can paradoxically contribute to the in vivo efficacy of CD4+Treg cells, perhaps by dictating a Treg ...
CD3+T cells were sorted from PBMCs from four AML patients (Additional file 1: Table S1) who had TCRζ deficiency and then transfected with TCRζ-IRES2-EGFP or IRES2-EGFP, respectively, by nucleofection [9]. Significant upregulation of TCRζ in TCRζ-IRES2-EGFP-transfected CD3+T cells ...
The aim of this study was to investigate the role of the transcription factors, AP-1 and NF-κB, in IL-6 and CXCL8 regulation in Jurkat T-cells. Results Phorbol myristate acetate (PMA) exposure resulted in an up-regulation of AP-1 and down-regulation of NF-κB activity, however, ...
Biology of IL-2 and its therapeutic modulation: Mechanisms and strategies. J Leukoc Biol. 2018 Apr;103(4):643-655. doi: 10.1002/JLB.2RI0717-278R. Epub 2018 Mar 9. PMID: 29522246. [14].Kalia V, Sarkar S. Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2-A ...
FunctionPlaysaroleintheinducibleexpressionofcytokinegenesinT-cells,especiallyintheinductionoftheIL-2,IL-3,IL- 4,TNF-alphaorGM-CSF. TissuespecificityExpressedinthymus,spleen,heart,testis,brain,placenta,muscleandpancreas. SequencesimilaritiesContains1RHD(Rel-like)domain. DomainRelSimilarityDomain(RSD)allowsDNA-...
Additionally, activated Akt has a role in the regulation of FOXO transcription factors [44]. In a study by Shi et al., human CRC cell line SW480 was co-cultured with CIK cells. The AMPK/Akt/mTOR pathway evaluation indicated that p-AMPK and p-Akt were upregulated, while FoxM1 and p-...
dose and T cell polarization may be both through a direct effect on differential CD3 signaling [13] and through the ability to modulate expression of co-stimulatory molecules expressed by CD4 cells; high antigen dose can favor Th1 development through dose-dependent up-regulation of CD40L [14]. ...