Finally, we have recently shown that CD30 triggering of activated Th cells by CD30L-expressingAPCs may represent an that the protooncogene c-maf, a basic region/leucine zipper transcriptionfactor, controls tissue-specific expression of IL-4. c-Maf is expressed in Th2 butE Maggi...
In this example, the selection process is simplified: a ligand, IL-12, and its receptor are shown selecting predominantly Th1-type effector cells. The ligand–receptor pairs may, however, be quite heterogeneous and include other soluble factors or cell-bound ligands discussed in this review. ...
Nave CD4T cells coordinate the immune response by acquiring an effector phenotype in response to cytokines. However, the cytokine responses in memory T cells remain largely understudied. Here we use quantitative proteomics, bulk RNA-seq, and single-cell RNA-seq of over 40,000 human nave and ...
[13] Starr T K, Jameson S C, Hogquist K A. Positive and negative selection of T cells[J/OL]. Annu Rev Immunol, 2003, 21: 139-176 [2021-12-06]. https://www.ncbi.nlm.nih.gov/pubmed/12414722. DOI: 10.1146/annurev.immun...
T cells. Signals from low-affinity pMHC and cytokines synergistically induce phosphorylation of the kinase Akt, metabolic changes and c-Myc transcription factor induction in CD8+T cells only in the presence of Themis. This function of Themis is mediated through Shp1 phosphatase, as peripheral ...
Activated CD8+ T cells also produce several cytokines that contribute to host defense, including IFNγ, TNFα, and lymphotoxin-α. IFNγ inhibits viral replication while increasing expression of MHC class I, improving the chance that an infected cell will be recogniz...
These cells are extremely important to cell immunity because they are required for most adaptive immune responses. T helper cells become activated when presented with antigens and have the ability to differentiate into cell subtypes. When activated, helper T cells multiply and secrete cytokines that ...
IL-2 is one of the most important cytokines in T cell activation, which is mainly secreted by CD4+ Th cells, NK, and CD8+ T cells. IL-2 enhances cytolytic activity, drives Treg cell development, suppresses immune cell responses, and promotes potential cell elimination functions through activat...
be seen whether the Th1 or Th2 cytokines produced by antigen-specific CD4(+) T cells provide effective regulation of the host immune defense against C... H Shiomi,A Masuda,S Nishiumi,... - 《Infection & Immunity》 被引量: 114发表: 2010年 dsRNA sensors and plasmacytoid dendritic cells in...
36 Although γδ T cells constitute a minor component of the overall T-cell population in peripheral lymphoid organs (<5% of total T cells), Th17 Cells in Lung Disease Th17 cells are a new lineage of T cells that express novel cytokines, such as IL-17A, IL-17F, and IL-22 (Fig 2)...