CytoImmune首席执行官Christina Coughlin博士说:“我们很高兴能分享我们的CAR-NK候选药物治疗胰腺癌的数据。这些基础数据基于CYTO NK-203的强大抗肿瘤活性,我们对这些发现感到鼓舞,并期待继续与City of Hope合作,以将这个项目继续向临床推进。” 工程化NK细胞治疗癌症的机会 自然杀伤细胞(Natural Killer cell,NK细胞)细胞...
chemical, and physical agents have been implicated in cancer causation. However, the mechanisms responsible for this uninhibited proliferation, following the initial insult(s), are still object of intense investigation.
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Chemical investigation on the methanol extract of Chaetomium globosum TW1-1, a fungus isolated from the common pillbug (Armadillidium vulgare), has resulted in the isolation of nine new highly oxygenated cytochalasan alkaloids, armochaetoglobins S–Z (1
Yuri was born on 11 December, 1951, in Zhukovsky, a city near Moscow known as a home to several major research institutes involved in designing aircraft, to a family of an engineer-researcher. While graduating from school, he chose biology as a field of further higher education. Today, we...
肿瘤来源的外泌体也表现出强烈的促肿瘤免疫反应。肿瘤细胞外泌体可以抑制T细胞和NK细胞活化,且促进Treg细胞功能(如携带PD-L1的肿瘤细胞外泌体可以抑制T细胞功能促进肿瘤生长)。除了Treg细胞外,肿瘤细胞外泌体还能抑制DC细胞活性并促进MDSC细胞的扩增。肿瘤细胞来源的外泌体也刺激巨噬细胞向促进癌症的M2期极化。