CYTO-102是一种由PD-L1阳性肿瘤反应性NK细胞(TRACK-NK™) 组成的通用型细胞疗法,通过对NK细胞进行基因修饰以分泌高水平的可溶性IL-15。 此次临床试验旨在评估CYTO-102单药或与atezolizumab(阿特珠单抗)联用治疗复发/难治性NSCLC患者的安全性和耐受性,以及关键的生物学终点包括NK细胞持久性和转运,肿瘤微环境的变化...
Hu Y, hang W, Zhang P, Ruan W, Zhu X (2013) Nematicidal activity of chaetoglobosin A produced by Chaetomium globosum NK102 against Meloidogyne incognita. J Agric Food Chem 61:41 Google Scholar Dou H, Song Y, Liu X, Gong W, Li E, Tan R, Hou Y (2011) Chaetoglobosin Fex from the...
The results confirm those of others (12) that most of the NK cells were not adherent to columns, and demonstrate (Table III) that the cytostatic activity is mediated both by non adherent as well as adherent cells. The adherent population of splenocytes (eluted by mechanical means) was ...
CASPubMedGoogle Scholar Shiseki M, Masuda A, Yoshinaga K, Mori N, Okada M, Motoji T, et al. Identification of the SOX5 gene as a novel IGH-involved translocation partner in BCL2-negative follicular lymphoma with t(12;14)(p12.2;q32). Int J Hematol. 2015;102(5):633–8. ArticleCAS...
“cold” node was a subclone derived from the other node. Additionally, transcriptome analysis identified that the cold lesion had low expression of HLA genes, CTLA-4, and CD274, while the "hot" node was rich in CD8 + and CD4 + lymphocytes, γδ T cells, and NK cells [90]....
All AML patients with CEBPA mutation except 1 had NK. Patients who had NK were significantly found mutated NPM1 (p < 0.001) or CEBPA (p = 0.002), but not significantly seen with FLT3-ITD mutation (p = 0.113). Median age in AML patients with FLT3-ITD, NPM1 and CEBPA ...
Parallelly, somatic (cyto)genomic variations were studied in autism. As a result, it was discovered that somatic mosaicism (aneuploidy) is a genetic risk factor for autism [102]. Furthermore, these studies demonstrated an unprecedentedly high prevalence of chromosomal heteromorphisms in autistic child...
Sfk1681 CD94/KLRD1 NK细胞表面抑制性受体CD94抗体 Sfk1682 CD58 淋巴细胞功能相关抗原-3抗体 Sfk1683 CCL27/CTACK 皮肤T细胞虏获趋化因子抗体 Sfk1684 ComplementC3 补体C3a过敏毒素抗体 Sfk1685 MacrophageInflammatoryProtein1gamma 巨噬细胞炎症蛋白-1γ抗体 Sfk1686 CD171 神经细胞粘附分子配体1抗体 Sfk1687 ...
rsitmo itlhaer tboin tdhien gbipnodritniogn poofrtthioenp eorft uthssei spteorxtiuns.sPisr ottoexiinnd. aPtraobtaenink adcacteasbsaionnk naucmcebsseirosn: Pneurtmusbseirsst:o Pxienrt(u1sPsRisT )to[4x6in], (S1-PCRDTT) ([44K6]6,...
UV irradiation significantly increased MCA 102 tumor cell sensitivity to lysis by both NK and NC cells. Analysis of the mechanisms involved in UV-induced NK sensitivity revealed that UV irradiation increased tumor cell susceptibility to lytic NK-derived granules. NC sensitivity of MCA 102UV tumor ...