CYTO-102是一种由PD-L1阳性肿瘤反应性NK细胞(TRACK-NK™) 组成的通用型细胞疗法,通过对NK细胞进行基因修饰以分泌高水平的可溶性IL-15。 此次临床试验旨在评估CYTO-102单药或与atezolizumab(阿特珠单抗)联用治疗复发/难治性NSCLC患者的安全性和耐受性,以及关键的生物学终点包括NK细胞持久性和转运,肿瘤微环境的变化...
Cutaneous extranodal NK/T-cell lymphoma: a clinicopathologic study of five caucasian cases with array-based comparative genomic hybridization. Blood. 2010;116(2):165–70. Article CAS PubMed Google Scholar Sun L, Li M, Huang X, Xu J, Gao Z, Liu C. High-resolution genome-wide analysis ...
Lymphopoiesis involves a series of maturational steps from HSCs to common lymphoid precursors to differentiated T, B, natural killer (NK), and plasma cells. Lymphocytes are often seen in the bone marrow but are infrequent (especially plasma cells) in nonpathologic states. These cell types are fur...
The results confirm those of others (12) that most of the NK cells were not adherent to columns, and demonstrate (Table III) that the cytostatic activity is mediated both by non adherent as well as adherent cells. The adherent population of splenocytes (eluted by mechanical means) was ...
Antonio-Nkondjio, C. et al. Review of malaria situation in Cameroon: technical viewpoint on challenges and prospects for disease elimination. Parasit. Vectors 12, 501 (2019). Article PubMed PubMed Central Google Scholar World Health Organization. WHO Guidelines for Malaria (ed. Global Malaria...
Sfk1681 CD94/KLRD1 NK细胞表面抑制性受体CD94抗体 Sfk1682 CD58 淋巴细胞功能相关抗原-3抗体 Sfk1683 CCL27/CTACK 皮肤T细胞虏获趋化因子抗体 Sfk1684 ComplementC3 补体C3a过敏毒素抗体 Sfk1685 MacrophageInflammatoryProtein1gamma 巨噬细胞炎症蛋白-1γ抗体 Sfk1686 CD171 神经细胞粘附分子配体1抗体 Sfk1687 ...
Human karyotype is usually studied by classical cytogenetic (banding) techniques. To perform it, one has to obtain metaphase chromosomes of mitotic cells. This leads to the impossibility of analyzing all the cell types, to moderate cell scoring, and to the extrapolation of cytogenetic data retrieved...
Parallelly, somatic (cyto)genomic variations were studied in autism. As a result, it was discovered that somatic mosaicism (aneuploidy) is a genetic risk factor for autism [102]. Furthermore, these studies demonstrated an unprecedentedly high prevalence of chromosomal heteromorphisms in autistic child...
In group of patients aged < 40 years (32 patients), NK, favorable, intermediate and adverse cytogenetic abnormalities were observed in 13 (41%), 4 (12.5%), 5 (15.5%) and 10 patients (31%), respectively. In contrast, NK, favorable, intermediate and adverse risk cytogenetic ...
The knowledge that cancer is a malignant form of uncontrolled growth has existed for over a century. Several biological, chemical, and physical agents have been implicated in cancer causation. However, the mechanisms responsible for this uninhibited prol