【题目】细胞周期的调控需要一系列蛋白的参与,其中的两类关键蛋白为细胞周期蛋白(cyclins)和依赖细胞周期蛋白的蛋白激酶(CDKs),cyclins在缩胞中的浓度会发生
目的:探讨Fas介导的细胞周期特异性细胞凋亡发生过程中,细胞周期蛋白(cyclins)和细胞周期依赖性蛋白激酶(cyclin-dependent kinases,CDKs)的变化规律,及其可能的调节机制。方法:以急性淋巴细胞白血病Molt-4细胞株为靶细胞,建立Fas介导的细胞周期特异性凋亡模型;采用cyclin/DNA双参数流式细胞术和Western印迹法检测cyclins的...
What role do Cyclins and CDKs play in the cell cycle? Phases of the Cell Cycle : The cell cycle is the process through which the cells of living organisms divide and grow. It can be divided into two interphases (the G1 and G2 phases), one DNA replication phase (the S phase), and...
目的 探讨Cyclins/CDKs在Fas介导的细胞凋亡过程中的作用机制.方法 以白血病细胞株(Molt-4和Jurkat细胞株)和健康人的外周血淋巴细胞为载体,用人重组Fas配体诱导稳定而又典型的细胞周期特异性凋亡模型;用 Cyclin/DNA双参数流式细胞术检测Cyclins的表达;用Western blot法检测CDK1和CDK2的磷酸化位点以及进一步确认Cyclins的...
目的:探讨Fas介导的细胞周期特异性细胞凋亡发生过程中,细胞周期蛋白(cyclins)和细胞周期依赖性蛋白激酶(cyclin-dependent kinases,CDKs)的变化规律,及其可能的调节机制。方法:以急性淋巴细胞白血病Molt-4细胞株为靶细胞,建立Fas介导的细胞周期特异性凋亡模型;采用cyclin/DNA双参数流式细胞术和Western印迹法检测cyclins的表达...
It is generally known that histone demethylases regulate gene transcription by altering the methylate status on histones, but their roles in cancers and the underlying molecular mechanisms still remain unclear. MYC-induced nuclear antigen (MINA) is repor
Our purpose was to examine temporal expressions of cyclins and CDKs during renal development and compensatory growth. During embryonic development the mRNA levels of all cyclins were high, and after birth their levels decreased at different rates. G2 and phase cyclins, cyclin A and B, decreased ...
网络细胞周期正调因子 网络释义 1. 细胞周期正调因子 如果细胞周期正调因子(cyclins-CDKs)过表达,就可使细胞增殖不依赖于促生长因素的作用;或负调因子(CKIs)表达下降乃至不 … www.qnr.cn|基于 1 个网页
Related to Cyclins:cell cycle,M-cyclin,CDK,Cyclin dependent kinase cy·clin (sī′klĭn) n. Any of a class of proteins that fluctuate in concentration at specific points during the cell cycle and that regulate the cycle by binding to a kinase. ...
U87 MG cells were arrested in S phase while U373 MG cells in G2/M phase on staurosporine treatment. Consistent with this observation, no change in G1 phase regulators viz., Cyclin D1, D3 and CDK4 was seen on staurosporine treatment. The levels of CDK2, CDC2, Cyclin A and Cyclin B ...