New insights into cyclins, CDKs, and cell cycle control. Seminars in Cell & Developmental Biology, London, n. 16, p. 311-321, 2005.Sanchez I, Dynlacht BD. New insights into cyclins, CDKs, and cell cycle control. Semin Cell Dev Biol. 2005;16(3):311-321....
Cyclins and cyclin-dependent kinases (CDKs) are proteins and enzymes, respectively, that play a huge role in regulating the cell cycle. To be more... Learn more about this topic: Cell Cycle & Mitosis | Definition & Steps from Chapter 5/ Lesson 5 ...
Progress in the eukaryotic cell cycle is driven by oscillations in the activities of CDKs (Cyclin-Dependent Kinases). CDK activity is controlled by periodic synthesis and degradation of positive regulatory subunits, Cyclins, as well as by fluctuations in levels of negative regulators, by CKIs (CDK...
Progression through the cell cycle is governed by the periodic activation and inactivation of cyclin-dependent kinase complexes (CDK–cyclins). Although th... Y Jing,S Kornbluth - 《Trends in Cell Biology》 被引量: 264发表: 1999年 Cell Cycle Checkpoint Control Mechanisms That Can Be Disrupted ...
Related to Cyclins:cell cycle,M-cyclin,CDK,Cyclin dependent kinase cy·clin (sī′klĭn) n. Any of a class of proteins that fluctuate in concentration at specific points during the cell cycle and that regulate the cycle by binding to a kinase. ...
The genes that regulate cell-cycle progression participate as targets of NR signaling and coordinate many of these responses. These cyclins and CDKs in turn feed back to modify NR activity. Proteins governing nuclear receptor (estrogen receptor 伪 (ER伪), androgen receptor (AR), TR, GR) ...
celldifferentiationandmetabolism.InthisReview,wefocusonthemainbiologicalareasinwhichsuchnon-canonicalfunctionsofcyclinsandCDKshavebeendocumented.WerestrictourReviewtointerphasecyclinsandCDKs—thatis,thoseoperatingintheG1,SandG2phases.Non-cellcycleCDKs,suchasCDK5,areonlydiscussedinthecontextoftheirinteractionswith...
Cdks, cyclins and CKIs: roles beyond cell cycle regulation. Development 2013; 140: 3079–3093. Article CAS Google Scholar Kouzarides T . Chromatin modifications and their function. Cell 2007; 128: 693–705. Article CAS Google Scholar Jenuwein T, Allis CD . Translating the histone code. ...
493 Accesses 74 Citations Explore all metrics Abstract The G1 phase of the cell cycle represents a period of commitment to cell division, both for cells stimulated to resume division from a resting or quiescent state, and for cells involved in repeated cell cycles. During this period, various...
Cyclin levels in the cell are dynamically regulated through tight control over both their rate of synthesis and degradation via ubiquitin-mediated proteolysis. These CDK activators also impart distinct substrate specificity to CDKs for the temporal regulation of cell division.Key Concepts:Cyclin levels ...