Although CDK4 and CDK6 associated with cyclin Ds have similar cell cycle regulatory function, increasing evidence shows distinct biological functions between CDK4 and Future perspectives on controlling CDK activities Though increasing evidence show that CDK4 and CDK6 carry out distinct functions in the...
细胞周期的调控 通过细胞周期各时相中各自特异性的细胞周期蛋白 实现,其中细胞周期蛋白( Cyclin) 、细胞周期蛋白依 赖性激酶( Cyclin-dependent kinases,CDKs) 和 CDK 抑制因子( CDK inhibitors,CKIs) 是参与细胞周期调 控的主要因子。而 Cyclin D1 是调控细胞周期 G1 期的关键蛋白,对细胞周期调控至关重要。
Cyclin A degra-dation employs preferentially used lysines and a cyclin box function other than Cdk1binding. Ramachandran V,Matzkies M,Dienemann A,et al. Cell Cycle . 2007Ramachandran, V., Matzkies, M., Dienemann, A., and Sprenger, F. (2007). Cyclin A degradation employs preferentially ...
作者通过功能获得性(gain-of-function)遗传筛选方法,在HCT116细胞中筛选能够引起HQ461药物抵抗的突变,发现其中最显著的突变发生在CDK12基因上,即CDK12 G731E和G731R。为了进一步确定CDK12 G731E和G731R的作用,作者在A549细胞中构建了CDK12 G731...
In general, all stages of the cell cycle are chronologically separated in humans and are triggered by cyclin-Cdk complexes which are periodically expressed and partially redundant in function. Cyclins are eukaryotic proteins that form holoenzymes with cyclin-dependent protein kinases (Cdk), which they...
Thus, presumably, lysines elsewhere in the protein are used when the preferred ones are absent and this requires the N-terminal signals. Furthermore, our results suggest that some function of the cyclin box other than Cdk1 binding promotes spindle checkpoint-independent recognition of Cyclin A by...
Interestingly, although some cyclin have a cyclin box, they do not have an activatable CDK: cyclin F, cyclin I, and cyclin G, for example. And cyclin I does not have the cell cycle regulatory function, it mainly acts on nerve cells....
function as regulators of CDK kinases.Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event.This cyclin forms a complex with and functions as a regulatory subunit of CDK2,whose activity is required for cell cycle G1/...
pendentkinases(CDKs)andCDKinhibitors(CKIs)playmajorrolesincellcycleregulations.CyclinD1,asakeyproteininG1phase, isamoresensitiveindicatorthanotherCyclins.Hereinwereviewedaboutthestructure,functionofCyclinD1anditsexpressionin tumourtissue,andalsopreliminarilyanalyzedtheapplicationofCyclinDininsectcellcycleregulation. ...