Here, we discuss the transcription network oscillator in the context of the historical view that CDKs form the central cell cycle oscillator. We also discuss the role of transcription networks in controlling temporal programs in a variety of biological systems and their ability to function as ...
Although CDK4 and CDK6 associated with cyclin Ds have similar cell cycle regulatory function, increasing evidence shows distinct biological functions between CDK4 and Future perspectives on controlling CDK activities Though increasing evidence show that CDK4 and CDK6 carry out distinct functions in the...
ARTICLES Activation and function of cyclin T–Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy ? 2002 Nature Publishing Group http://www.nature.com/naturemedicine MOTOAKI SANO1,3, MAHA ABDELLATIF6, HIDEMASA OH1,3, MIN XIE1,3, LUIGI BAGELLA7, ANTONIO ...
细胞周期的调控 通过细胞周期各时相中各自特异性的细胞周期蛋白 实现,其中细胞周期蛋白( Cyclin) 、细胞周期蛋白依 赖性激酶( Cyclin-dependent kinases,CDKs) 和 CDK 抑制因子( CDK inhibitors,CKIs) 是参与细胞周期调 控的主要因子。而 Cyclin D1 是调控细胞周期 G1 期的关键蛋白,对细胞周期调控至关重要。
Interestingly, although some cyclin have a cyclin box, they do not have an activatable CDK: cyclin F, cyclin I, and cyclin G, for example. And cyclin I does not have the cell cycle regulatory function, it mainly acts on nerve cells....
et al. Cyclin D1 protein expression and function in human breast cancer. Int. J. Cancer 57, 353–361 (1994). CAS PubMed Google Scholar Khatib, Z. A. et al. Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. Cancer Res. 53, 5535–5541 (1993). CAS PubMed ...
细胞周期的恰当调控,对于细胞的生长,分化及分裂过程中极其重要的角色.细胞周期调控主要是通过蛋白质激酶介导的信号转导方式完成的.Cyclins/Cdks蛋白激酶为细胞周期调控最关键的分子,其中cyclin E/CDK2在细胞周期的Gl/S检验点转换过程中发挥着极其重要的作用.目前已经发现了一些蛋白与cyclinE/CDK2相互作用,并在Gl/S检验...
function. A recent study reported that overexpression of MCPIP1 caused G1/S checkpoint blockade, resulting in cell cycle arrest at G1 stage, which relies on the ribonuclease domain to reduce the key cyclins and CDKs involved in G1/S transformation in neuroblastoma cells30. Accordingly, further...
In general, all stages of the cell cycle are chronologically separated in humans and are triggered by cyclin-Cdk complexes which are periodically expressed and partially redundant in function. Cyclins are eukaryotic proteins that form holoenzymes with cyclin-dependent protein kinases (Cdk), which they...