Bird RC: The cyclin/cyclin-dependent kinase (cdk) complex: regulation of cell cycle progression and nuclear disassembly: In: Nuclear Structure and Gene Expression (Bird RC, Stein GS, Lian JB and Stein JL, eds). San Diego, Academic Press, 1997, pp 145-174....
Cyclin A is the ONLY cyclin that plays a role in regulation of two cell cycle stages. It can activate two CDKs – CDK2 and CDK1. When Cyclin A forms a complex with CDK2, it allows the cell to progress to S phase. Meanwhile, binding of Cyclin A to CDK1 allows entry into M phase...
Cell cycle regulation: p53-p21-RB signaling Article Open access 31 March 2022 HDAC activity is dispensable for repression of cell-cycle genes by DREAM and E2F:RB complexes Article Open access 24 May 2024 Altered G1 signaling order and commitment point in cells proliferating without CDK4/6...
DNA replication and mitosis are dependent on the activity of cyclin-dependent protein kinase(CDK) enzymes, which are heterodimers of a catalytic subunit with a cyclin subunit. Cyclinbinding to specific individual proteins is thought to provide potential substrates to Cdk. Protein binding by cyclins is...
The retinoblastoma protein (pRb) plays a crucial role in cell-cycle regulation.13 Recently, the cyclin-C/cyclin-dependent kinase-3 (CDK3) complex was shown to facilitate exit from G0 into the cell cycle by pRb phosphorylation at serines (S) 807 and 811. This cyclin-C- associated kinase ...
Cell Cycle Progression and Synchronization: An Overview 2022, Methods in Molecular Biology Regulation of cell cycle progression by growth factor-induced cell signaling 2021, Cells Cdk4/6 inhibitors in melanoma: A comprehensive review 2021, Cells View all citing articles on ScopusView...
Dual regulation of the anaphase promoting complex in human cells by cyclin A-Cdk2 and cyclin A-Cdk1 complexes. Cell Cycle 2006 ; 5:661-6; PMID: 16582612 ; http://dx.doi.org/ 10.4161/cc.5.6.2604 [Taylor & Francis Online] ,Cyclin A/Cdk2 regulates Cdh1 and claspin during late S/G2...
What happens if cell cycle regulators don't function properly? Describe or give a definition of the following: Cell cycle. Determine if the following statement concerning the regulation of CDK/cyclin complexes is true or false: Cyclin/CDK complexes are frequently targets of cell cycle checkpoint ...
L. (2000) Cyclin-dependent kinase inhibitors: useful targets in cell cycle regulation. Journal of Medicinal Chemistry, 43, 1-18.Sielecki, T. M.; Boylan, J. F.; Benfield, P. A.; Trainor, G. L. Cyclin-Dependent Kinase Inhibitors: Useful Targets in Cell Cycle Regulation. J. Med. Chem...
Cyclin-dependent protein kinases and the regulation of the eukaryotic cell cycle, p. 179–201 - Hoffmann - 1996 () Citation Context ...s are governed by a family of cyclin-dependent kinases (Cdks). Cdk activities are determined by cyclin-binding, small Cdk inhibitor proteins and both ...