Cyclin A is the ONLY cyclin that plays a role in regulation of two cell cycle stages. It can activate two CDKs – CDK2 and CDK1. When Cyclin A forms a complex with CDK2, it allows the cell to progress to S phase. Meanwhile, binding of Cyclin A to CDK1 allows entry into M phase...
1) cyclin-CDK complex cyclin-CDK复合物 2) Composites [英]['kəmpəzit] [美][kəm'pɑzɪt] 复合物 1. Research Progress in Magnetic Polymer Matrix Nanocomposites; 高分子基磁性纳米复合物的研究进展 2. Preparation method of the composites of ethylene vinylacetate with nano-SiO_2...
We have investigated which component in the cyclin-cdk complex determines its substrate specificity. The A- and B-type cyclin-cdk complexes phosphorylated histone H1 and their cyclin subunits in an indistinguishable manner, irrespective of the catalytic subunit, p33cdk2 or p34cdc2. In contrast, ...
Wittenberg C, Reed SI (1988) Control of the yeast cell cycle is associated with assembly/disassembly of the Cdc28 protein kinase complex. Cell 54:1061–1072 CASGoogle Scholar Wu L, Hepler PK, John PCL (1997) Themetlmutation inChlamy-domonas reinhardtiicauses arrest at mitotic metaphase with ...
Hyperphosphorylation occurs in a cyclin-dependent kinase (CDK)·cyclin-dependent manner with CDK1·cyclin B as the major kinase complex, although CDK2 and cyclin A also appear to be important. We have mapped two CDK phosphorylation sites, serines 368 and 423, which play a role in defining ...
The dominant model for eukaryotic cell cycle control proposes that cell cycle progression is driven by a succession of CDK complexes with different substrate specificities. However, in fission yeast it has been shown that a single CDK complex generated b
Given this alternative view of the mitotic cycle we tested whether a single CDK–cyclin complex could also drive the programme of the more complex meiotic cell cycle. We found that the Cdc13-Cdc2 fusion was unable to undergo the second meiotic nuclear division but did efficiently progress into ...
How does the cyclinCDKcomplex regulate the cell cycle? Explain. Cell Cycle: A cell cycle is an important event through which the division of cells takes place. It takes place in four-phase such as G1, S, G2, and M phases. It consists of two main stages interphase and mitotic stage....
Regulation of PHO4 nuclear localization by the PHO80-PHO85 cyclin-CDK complex. Examines the subcellular localization of the transcription factor PHO4 in wild-type cells grown in low or high phosphate medium. Role of PHO4 in the induct... O'Neill,Elizabeth,M.,... - 《Science》 被引量: ...
[83]. In contrast, the function of Cdk9 and its yeast homolog, Bur1, in the maintenance of genome integrity appears to be direct and independent of the modulation of DDR gene expression, as judged by results from genome-wide expression arrays [84,86]. Cdk9 was found in complex with ...