Bird RC: The cyclin/cyclin-dependent kinase (cdk) complex: regulation of cell cycle progression and nuclear disassembly: In: Nuclear Structure and Gene Expression (Bird RC, Stein GS, Lian JB and Stein JL, eds). San Diego, Academic Press, 1997, pp 145-174.
DNA replication and mitosis are dependent on the activity of cyclin-dependent protein kinase(CDK) enzymes, which are heterodimers of a catalytic subunit with a cyclin subunit. Cyclinbinding to specific individual proteins is thought to provide potential substrates to Cdk. Protein binding by cyclins is...
Explain how cyclin and cyclin-dependent kinases regulate progression through the cell cycle and various checkpoints. Describe the protein complexes that regulate the cell cycle, and explain how they do so. Describe how cyclins, Cdk, and checkpoints interact to regulate the rate of the cell cycle...
CDK(cyclin-dependent kinase,周期蛋白依赖性激酶)是一类重要的蛋白激酶。它们的活性受到细胞周期蛋白的正调节和CDK抑制剂(CKIs)的抑制,其激活状态的波动可以通过转录和翻译后修饰(通常是磷酸化)以及泛素-蛋白酶体系统对细胞周期蛋白和CKIs的快速循环降解来调节。磷酸化或与CKIs的关联确保了过程中快速可逆的变化,泛素...
During S phase, Cyclin A resides in the nucleus. It directs the initiation and completion of DNA replication. Critically, Cyclin A ensures that DNA replication only occurs ONCE per cell cycle by preventing assembly of excessive replication complexes. How does it accomplish this?
Cell 98, 859–869 (1999). CAS PubMed Google Scholar Lundberg, A. S. & Weinberg, R. A. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell. Biol. 18, 753–761 (1998). CAS PubMed PubMed Central ...
本研究针对登革病毒(DENV)感染导致血小板减少症的关键机制,首次系统揭示了DENV2血清型通过选择性调控巨核细胞(MEG-01)内CDK4、CDK1和Cyclin B1等细胞周期关键蛋白,重塑内复制(endomitosis)进程以促进病毒复制的分子机制。研究人员采用蛋白质微阵列筛选结合基因沉默技术,发现DENV2显著上调CDK4/CDK1-Cyclin B1复合体活性...
Dual regulation of the anaphase promoting complex in human cells by cyclin A-Cdk2 and cyclin A-Cdk1 complexes. Cell Cycle 2006 ; 5:661-6; PMID: 16582612 ; http://dx.doi.org/ 10.4161/cc.5.6.2604 [Taylor & Francis Online] ,Oakes, V.; Wang, W.; Harrington, B.; Lee, W.J.; ...
This is the first report that avian reovirus p17 possesses broad inhibitory effects on cell cycle CDKs, cyclins, CDK–cyclin complexes, and CDK-activating kinase activity in various mammalian, avian, and cancer cell lines. Suppression of CDK activity by p17 occurs by direct binding to CDKs, ...
而CDK12-cyclin K复合物可诱导cyclin E1的Ser366磷酸化,阻止cyclin E1与CDK2形成复合物,进而导致G1/S期阻滞[12]。Chirackal Manavalan等[9]研究发现,抑制CDK12的表达将导致拓扑异构酶Ⅱβ结合蛋白1(topoisomerase Ⅱβ binding protei...