or Rb for short. Rb is bound to E2F, a transcription factor. When the CD-CDK4 and CD-CDK6 complexes partially phosphorylate Rb, it loosens its grip on E2F. E2F can then activate transcription of the cyclin E gene. Cyclin E binds CDK...
DNA replication and mitosis are dependent on the activity of cyclin-dependent protein kinase(CDK) enzymes, which are heterodimers of a catalytic subunit with a cyclin subunit. Cyclinbinding to specific individual proteins is thought to provide potential substrates to Cdk. Protein binding by cyclins is...
Arellano M and Moreno S (1997) Regulation of CDK/cyclin complexes during the cell cycle. Int J Biochem Cell Biol 29,559-573.Arellano, M. & Moreno, S. Regulation of CDK/cyclin complexes during the cell cycle. Int. J. Biochem. Cell Biol. 29, 559-73 (1997)....
Determine if the following statement concerning the regulation of CDK/cyclin complexes is true or false: Cyclin/CDK complexes are frequently targets of cell cycle checkpoint pathways. Describe the three phases of a bacterial cell cycle. Describe why eukaryotic cells being compartmentalized can make th...
B, in vitro kinase assay with the indicated cyclin·CDK complexes and FOXK2(189–660) (top) and histone H1 (bottom) substrates. Phosphorylated products were detected by autoradiography. Truncated fragments of FOXK2(189–660) are marked with asterisks. C, GST pull-down assay using GST or GST...
The dominant model for eukaryotic cell cycle control proposes that cell cycle progression is driven by a succession of CDK complexes with different substrate specificities. However, in fission yeast it has been shown that a single CDK complex generated by the fusion of the Cdc13 cyclin with the ...
[2,3]. Another group of cyclin/Cdk complexes, including cyclin H/Cdk7 and cyclin T/Cdk9, have cell cycle-independent activities. These complexes are engaged in the regulation of transcription and posttrancriptional mRNA processing via the phosphorylation of the C-terminal domain (CTD) of RNA...
complex is sufficient for both mitotic and meiotic progression in fission yeast Pilar Gutie´rrez-Escribano1,w & Paul Nurse1,2,3 The dominant model for eukaryotic cell cycle control proposes that cell cycle progression is driven by a succession of CDK complexes with different substrate ...
This chapter primarily explores the understudied topic of CDK/cyclin complex functionality during the DNA damage response. We detail how CDK/cyclin complexes perform dual roles both as targets of DNA damage checkpoint signaling as well as effectors of DNA repair. Additionally, we discuss the ...
Redistribution of the CDK inhibitor p27 between different cyclin-CDK complexes in the mouse fibro- blast cell cycle and in cells arrested with lovastatin ... RY Poon,H Toyoshima,T Hunter - 《Mol.biol.cell》 被引量: 411发表: 1995年 Cell cycle-dependent phosphorylation of p27 cyclin-dependent...