One of the emerging concepts in the cell cycle field is that progress through the cycle is determined at discrete points, called checkpoints, by a family of closely related protein kinases. This family has been christened the 'cyclin-dependent kinases' (CDKS), because they are only activated...
Progression through the cell cycle is governed by the periodic activation and inactivation of cyclin-dependent kinase complexes (CDK–cyclins). Although th... Y Jing,S Kornbluth - 《Trends in Cell Biology》 被引量: 264发表: 1999年 Cell Cycle Checkpoint Control Mechanisms That Can Be Disrupted ...
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This chapter focuses on the genetic alterations of cyclins, cyclin dependent kinases (Cdk), and Cdk inhibitors in human cancer. Contemporary research into the molecular basis of cancer has two central tenets. The first is that cancer arises through alterations in the genetic make-up of the tumor...
This transition from G1 to S phase is called START and marks a point of no return. Hence, if a cell overcomes this checkpoint and commits to entering S phase, it has to progress through the entire cell cycle. Accordingly, this checkpoint has to be tightly controlled to ensure that the ...
Mutations in Drosophila cyclin A and cdk1 result in transformation of mitotic into endoreduplication cycles (38, 22). Higher eukaryote cdk1, therefore, is also required for both M phase and the coupling of S and M phase. Cdk1 complexes might prolong the block of reinitiation of DNA ...
Cyclin A/B RxL inhibition results in accumulation of cells in the G2/M phase of the cell cycle which leads to apoptosis both in vitro and in vivo. A separate study (Singh et al. AACR 2023) utilizing a CRISPR screen identified that genes of the spindle assembly checkpoint (SAC) are ...
CDK4cell cycleproliferationcancerovergrowthD-type cyclins encode G1/S cell cycle checkpoint proteins, which play a crucial role in defining cell cycle exit and progression. Precise control of cell cycle exit is vital during embryonic development, with defects in the pathways regulating intracellular D...
The canonical CBD (PFAM 00134) is a sequence of approximately 100 amino acids arranged in five α-helices, and is responsible for binding and activation of CDKs [5,6,7]. Whereas all cyclins possess a CBD at the N-terminus half [8], some also exhibit an extra CBD (PFAM 02984 and PFA...
Human cdc25C is a dual-specificity phosphatase involved in the regulation of cell cycle progression in both unperturbed cells and in cells subject to DNA damage or replication checkpoints. In this study, we describe the structure-function relationship of an essential domain of human cdc25C that ...